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Core Outcome Set development for LEPtospirosis trials (COS-LEP): a study protocol to develop a core outcome set for the evaluation of clinical therapeutic interventions for human leptospirosis.
Trials
January 2025
Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Background: Leptospirosis is a zoonotic bacterial infection occurring worldwide. It is of particular public health concern due to its global distribution, epidemic potential and high mortality without appropriate treatment. The method for the management of leptospirosis, particularly in severe disease, is clouded by methodological inconsistency and a lack of standardized outcome measures.
View Article and Find Full Text PDFGrenadian cats as potential reservoir for Leptospira.
PLoS Negl Trop Dis
December 2024
St. George's University, School of Veterinary Medicine, Department of Pathobiology, Grenada, West Indies.
Leptospirosis is a spirochetal disease caused by Leptospira spp. bacteria with global distribution affecting multiple mammalian species, including humans. The disease is endemic in many geographic areas and is of particular concern in tropical regions with abundant rainfall, such as the Caribbean.
View Article and Find Full Text PDFLeptospirosis outbreak in Ecuador in 2023: A pilot study for surveillance from a One Health perspective.
One Health
December 2024
One Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Leptospirosis is a neglected zoonotic disease that is endemic in tropical regions, including Ecuador. It is caused by spirochetes of the genus , which can infect humans through animal reservoirs such as rats and dogs, or through contact with contaminated water or soil. In March 2023, public health authorities declared a concerning outbreak of leptospirosis in Durán Cantón, located in the Coastal region of Ecuador.
View Article and Find Full Text PDFSeroepidemiology of human leptospirosis in the Dominican Republic: A multistage cluster survey, 2021.
PLoS Negl Trop Dis
December 2024
University of Queensland Centre of Clinical Research (UQCCR), University of Queensland, Brisbane, Australia.
Little is known about the epidemiology of leptospirosis in the Dominican Republic, the second most populous country in the Caribbean. We report on findings from a multi-stage household survey across two regions in the country that reveals a previously under-estimated burden of human Leptospira infection. Our findings, based on the reference-standard microscopic agglutination test, indicate a complex picture of serogroup diversity, spatial heterogeneity in infection and risk, and a marked discrepancy between reported cases and serologically estimated infections.
View Article and Find Full Text PDFBurden of leptospirosis in Brazil in the last decade.
Rev Saude Publica
December 2024
Pontifícia Universidade Católica do Paraná. Laboratório de Doenças Infecciosas Emergentes. Curitiba, PR, Brasil.
To correlate the incidence of leptospirosis with sociodemographic data in the Brazilian Unified Health System from 2011 to 2022. This ecological study used national health and economic secondary data sources. Secondary analyses summarized the scenario of disease-related hospitalizations among federative units.
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