AI Article Synopsis

  • This study investigates the relationship between atrial fibrillation (AF) and cognitive impairment, highlighting how AF burden affects cognitive function in patients.
  • It involved 253 patients with non-valvular AF, using 14-day ECG patches to measure AF burden and the Montreal Cognitive Assessment (MoCA) for cognitive evaluation.
  • Findings show that higher AF burden correlates with poorer cognitive scores, older age, worse heart function, and significant predictors include age, AF burden, and depression levels. Further research is needed to see if lowering AF burden can help preserve cognitive abilities.

Article Abstract

Background: Accumulating evidence has demonstrated an association between clinical atrial fibrillation (AF) and cognitive impairment. This study aimed to further clarify the impact of AF burden on cognitive function based on detailed electrophysiological recordings and standardized assessments of cognitive function.

Methods: This prospective cohort study, conducted at the Cardiac Electrophysiology Clinic of a tertiary center, included patients with non-valvular AF. AF burden was evaluated using 14-day patch-based electrocardiography. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA).

Results: Enrolled patients (n = 253) were grouped according to the median AF burden (13.52%). Patients with higher AF burden were significantly older and had larger left atrium size, a worse ejection fraction, and a lower MoCA score than those with lower AF burden. Predictors of MoCA score included age, CHADS-VASc score, AF burden, and Center for Epidemiologic Studies Depression Scale scores. The association between MoCA scores and AF burden remained significant after adjustment for demographic characteristics, underlying diseases, and echocardiographic parameters (standardized beta coefficient: -0.159, 95% confidence interval: -0.020 to -0.004, p = 0.004).

Conclusion: AF burden is associated with cognitive function in patients with AF. Further studies are required to determine whether reducing AF burden can preserve cognitive function in these patients.

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Source
http://dx.doi.org/10.1016/j.ijcard.2023.01.007DOI Listing

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