Depending on its adsorption conformation on the Au(111) surface, a zwitterionic single-molecule machine works in two different ways under bias voltage pulses. It is a unidirectional rotor while anchored on the surface. It is a fast-drivable molecule vehicle (nanocar) while physisorbed. By tuning the surface coverage, the conformation of the molecule can be selected to be either rotor or nanocar. The inelastic tunneling excitation producing the movement is investigated in the same experimental conditions for both the unidirectional rotation of the rotor and the directed movement of the nanocar.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsnano.2c12128 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preclinical evaluation of antigen-sensitive B7-H3-targeting nanobody-based CAR-T cells in glioblastoma cautions for on-target, off-tumor toxicity.
J Immunother Cancer
November 2024
Translational Oncology Research Center (TORC), Department of Biomedical Sciences, Laboratory for Molecular and Cellular Therapy (LMCT), Vrije Universiteit Brussel, Brussels, Belgium.
Background: Glioblastoma is the most common lethal primary brain tumor, urging evaluation of new treatment options. Chimeric antigen receptor (CAR)-T cells targeting B7 homolog 3 (B7-H3) are promising because of the overexpression of B7-H3 on glioblastoma cells but not on healthy brain tissue. Nanobody-based (nano)CARs are gaining increasing attention as promising alternatives to classical single-chain variable fragment-based (scFv)CARs, because of their single-domain nature and low immunogenicity.
View Article and Find Full Text PDFKnocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion.
Cancer Immunol Res
September 2024
Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
CD70 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy for the treatment of both solid and liquid malignancies. However, the functionality of CD70-specific CAR T cells is modest. We optimized a CD70-specific VHH-based CAR (nanoCAR).
View Article and Find Full Text PDFToward steering the motion of surface rolling molecular machines by straining graphene substrate.
Sci Rep
November 2023
Nano Robotics Laboratory, Mechanical Engineering Department, Sharif University of Technology, Tehran, Iran.
The surface rolling molecular machines are proposed to perform tasks and carrying molecular payloads on the substrates. As a result, controlling the surface motion of these molecular machines is of interest for the design of nano-transportation systems. In this study, we evaluate the motion of the nanocar on the graphene nanoribbons with strain gradient, through the molecular dynamics (MD) simulations, and theoretical relations.
View Article and Find Full Text PDFFramework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies.
J Immunother Cancer
November 2023
Department of Laboratory Medicine, University of California, San Francisco, California, USA
Background: Approximately 50% of patients who receive anti-CD19 CAR-T cells relapse, and new immunotherapeutic targets are urgently needed. We recently described CD72 as a promising target in B-cell malignancies and developed nanobody-based CAR-T cells (nanoCARs) against it. This cellular therapy design is understudied compared with scFv-based CAR-T cells, but has recently become of significant interest given the first regulatory approval of a nanoCAR in multiple myeloma.
View Article and Find Full Text PDFFullerenes containing water molecules: a study of reactive molecular dynamics simulations.
Phys Chem Chem Phys
December 2023
Department of Physical Chemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
A different technique was used to investigate fullerenes encapsulating a polar guest species. By reactive molecular dynamics simulations, three types of fullerenes were investigated on a gold surface: an empty C, a single HO molecule inside C (HO@C), and two water molecules inside C ((HO)@C). Our findings revealed that despite the free movement of all fullerenes on gold surfaces, confined HO molecules within the fullerenes result in a distinct pattern of motion in these systems.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!