AI Article Synopsis
- 3D-printed scaffolds made from biodegradable polymers, specifically PTMC/PCL/TCP composites, are being used for effective bone repair and regeneration, minimizing the need for additional surgeries.
- These scaffolds exhibit favorable properties such as low cytotoxicity, good biocompatibility, and support for cell proliferation, particularly in osteoblast and bone marrow stem cell lines.
- The scaffolds are capable of enhancing bone induction and regeneration, making them a promising option for treating bone defects.
Article Abstract
Three-dimensional (3D)-printed scaffolds of biodegradable polymers have been increasingly applied in bone repair and regeneration, which helps avoid the second surgery. PTMC/PCL/TCP composites were made using poly(trimethylene carbonate), poly(ε-caprolactone), and β-tricalcium phosphate. PTMC/PCL/TCP scaffolds were manufactured using a biological 3D printing technique. Furthermore, the properties of PTMC/PCL/TCP scaffolds, such as biodegradation, mechanic properties, drug release, cell cytotoxicity, cell proliferation, and bone repairing capacity, were evaluated. We showed that PTMC/PCL/TCP scaffolds had low cytotoxicity and good biocompatibility, and they also enhanced the proliferation of osteoblast MC3T3-E1 and rBMSC cell lines, which demonstrated improved adhesion, penetration, and proliferation. Moreover, PTMC/PCL/TCP scaffolds can enhance bone induction and regeneration, indicating that they can be used to repair bone defects .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831063 | PMC |
| http://dx.doi.org/10.18063/ijb.v9i1.641 | DOI Listing |
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