AI Article Synopsis
- Bio-based production of chemicals and materials is crucial for sustainability and improving human health, driving interest in metabolic engineering (ME).
- ME involves modifying cellular systems to enhance the production of beneficial chemicals and reduce harmful ones, leveraging advancements in synthetic biology, systems biology, and AI over the past 30 years.
- The review covers the evolution of ME, its impact on sustainable chemical production and environmental health, and discusses future challenges and perspectives in the field.
Article Abstract
Bio-based production of chemicals and materials has attracted much attention due to the urgent need to establish sustainability and enhance human health. Metabolic engineering (ME) allows purposeful modification of cellular metabolic, regulatory, and signaling networks to achieve enhanced production of desired chemicals and degradation of environmentally harmful chemicals. ME has significantly progressed over the past 30 years through further integration of the strategies of synthetic biology, systems biology, evolutionary engineering, and data science aided by artificial intelligence. Here we review the field of ME from its emergence to the current state-of-the-art, highlighting its contribution to sustainable production of chemicals, health, and the environment through representative examples. Future challenges of ME and perspectives are also discussed.
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| http://dx.doi.org/10.1016/j.tibtech.2022.12.014 | DOI Listing |
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