The field of radionuclide therapy (RNT) for prostate cancer (PC) is growing rapidly, with recent Food and Drug Administration approval of the first Lu-PSMA ligand. We aimed to develop the first patient-reported outcome (PRO) measure for PC patients receiving RNT. We identified relevant symptoms and toxicities by reviewing published trials and interviews with PC patients receiving RNT ( = 29), caregivers ( = 14), and clinicians ( = 11). Second, we selected items for measure inclusion. Third, we refined the item list with input from experts in RNTs and PROs. Fourth, we finalized the Functional Assessment of Cancer Therapy-Radionuclide Therapy (FACT-RNT) with patient input. This multistep process yielded a brief 15-item measure deemed by key stakeholders to be relevant and useful in the context of RNT for PC. The FACT-RNT is a new standardized tool to monitor relevant symptoms and toxicities among PC patients in RNT trials and real-world settings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241017 | PMC |
| http://dx.doi.org/10.2967/jnumed.122.264946 | DOI Listing |
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