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Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins.
Biologics
March 2023
Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Introduction: Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins (ACDMPV) is a fatal congenital disease resulting from a pulmonary vascular endothelial deficiency of FOXF1, producing abnormal morphogenesis of alveolar capillaries, malpositioned pulmonary veins and disordered development of lung lobes. Affected neonates suffer from cyanosis, severe breathing insufficiency, pulmonary hypertension, and death typically within days to weeks after birth. Currently, no treatment exists for ACDMPV, although recent murine research in the Kalinichenko lab demonstrates nanoparticle delivery improves survival and reconstitutes normal alveolar-capillary architecture.
View Article and Find Full Text PDFRe: Retro-orbital alveolar soft-part sarcoma in a 76-year-old female: case report and review of the literature.
Can J Ophthalmol
April 2023
Department of Ophthalmology, University of Ottawa, Ottawa, ON. Electronic address:
Reply: Retro-orbital alveolar softpart sarcoma in a 76-year-old female: case report and review of the literature.
Can J Ophthalmol
April 2023
Department of Ophthalmology, University of CAornia-Irvine, Irvine, CA; Head and Neck Pathology Consultations, Woodland Hills, CA. Electronic address:
Retro-orbital alveolar soft-part sarcoma in a 76-year-old female: case report and review of the literature.
Can J Ophthalmol
December 2022
University of California-Irvine. Irvine, Calif; Kaiser Permanente-South Bay. Harbor City, Calif. Electronic address:
From Head to Toe: Granulomatosis with Polyangiitis.
Radiographics
November 2021
From the Departments of Radiology (M.I.G.S., Y.K., G.R.S., J.A.C.A., Y.K.S., D.A.S.N., I.A.R.), Pathology (F.C.G.), and Immunology and Rheumatology (A.H.A.), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Tlalpan, Mexico City, Mexico 14080.
Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmic antibody-associated vasculitis. It is an uncommon multisystem disease involving predominantly small vessels and is characterized by granulomatous inflammation, pauci-immune necrotizing glomerulonephritis, and vasculitis. GPA can involve virtually any organ.
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