AI Article Synopsis
- Gene expression is a dynamic process involving both consistent protein expression and rapid changes in production based on regulatory mechanisms.
- Transcription termination, alongside initiation, is crucial for controlling gene expression and is linked to the processing of mRNA following transcription.
- The regulation of transcription termination can vary in response to cellular signals, affecting the stability and production of mature RNA transcripts, particularly in eukaryotic cells using RNA polymerase II.
Article Abstract
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent and steady expression of some proteins as well as the rapidly changing production of other proteins. Transcription initiation has been a major focus of study because it is highly regulated. However, termination of transcription also plays an important role in controlling gene expression. Transcription termination on protein-coding genes is intimately linked with 3' end cleavage and polyadenylation of transcripts, and it generally results in the production of a mature mRNA that is exported from the nucleus. Termination on many non-coding genes can also result in the production of a mature transcript. Termination is dynamically regulated-premature termination and transcription readthrough occur in response to a number of cellular signals, and these can have varied consequences on gene expression. Here, we review eukaryotic transcription termination by RNA polymerase II (RNAPII), focusing on protein-coding genes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614299 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2022.12.021 | DOI Listing |
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