Background: The influence of sugammadex exposure during pregnancy on progesterone withdrawal and miscarriage is unknown. We aimed to compare the fetal outcomes in pregnant patients who had undergone non-obstetric surgery with and without sugammadex.
Methods: We retrospectively reviewed the medical charts of pregnant women who underwent non-obstetric surgery at three tertiary perinatal care centers in Japan from January 2013 to December 2020. The women were divided into those who received general anesthesia with sugammadex (GA with SGX) and those who received general anesthesia without sugammadex (GA without SGX). We compared miscarriages and preterm births within four weeks after surgery.
Results: Among the 124 women, 73 and 51 were included in the GA with SGX and GA without SGX groups, respectively. The two groups showed no differences in the rate of miscarriages or preterm births (3.0 % vs 4.3 %; odds ratio 1.42, 95 % confidence interval 0.19 to 10.47; P = 1.00). The SGX and no SGX groups were missing outcomes for 8.2 % and 7.8 % of cases, respectively.
Conclusions: Having GA with SGX or GA without SGX did not result in different rates of miscarriage or preterm birth within four weeks after the procedure. These findings do not exclude a potential association between sugammadex exposure during pregnancy and adverse pregnancy outcomes. Missing data may have obscured possible adverse outcomes from sugammadex exposure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijoa.2022.103620 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Laparoscopic appendectomy secondary to afebrile acute perforated appendicitis mimicking threatened abortion in first trimester pregnancy in Tanzania: A case report.
Int J Surg Case Rep
January 2025
Department of General Surgery, Kamanga Medics Hospital, P.O. Box 5228, Mwanza, Tanzania.
Introduction: Appendicitis in pregnancy is the most common non-obstetric surgical condition which requires urgent evaluation and immediate intervention in a multidisciplinary approach. Pregnancy anatomical and physiological changes can mask the presentation of appendicitis and poses both diagnostic and management challenges.
Case Presentation: A 32 year old female, G3P2L2 at gestation age of 11 weeks by USS, presented with recurrent episodes of acute abdominal pain for one day, afebrile but accompanied with poor appetite, nausea and vomiting along episodes of per vaginal spotting which started three days prior.
Mode of birth in nulliparous term singleton pregnancies in vertex presentation before and after implementation of an evidence-based intervention: quality-improvement study.
J Matern Fetal Neonatal Med
December 2025
2nd Department of Gynecology and Obstetrics, University Hospital Bratislava and Comenius University, Bratislava, Slovakia.
Article Synopsis
- The study aimed to evaluate how a quality improvement intervention affected birth methods in first-time mothers with single, head-down babies.
- The comparison of data from two different time periods showed a significant drop in cesarean section rates from 30.89% to 13.31% after the intervention, along with decreases in both elective and emergency cesarean sections.
- The findings suggest that with targeted strategies and stakeholder engagement, it's possible to lower cesarean rates without compromising fetal health outcomes.
Gallbladder Perforation in a Pregnant Patient: A Case Report and Considerations of Surgical Approach.
Cureus
November 2024
Human Anatomy Department, Clinical-Surgical Research Group (GICQx), Universidad Autónoma de Nuevo León, Monterrey, MEX.
Gallbladder disease is a frequent indication for non-obstetric surgical intervention during pregnancy. Gallbladder perforation (GBP) during pregnancy is an uncommon but severe pathology that usually requires immediate attention, and it represents a challenge for surgeons. We present the case of a GBP in a pregnant patient alongside a discussion of available surgical approaches.
View Article and Find Full Text PDFAnesthesia for non-obstetric surgery during late term pregnancy in mares.
PLoS One
November 2024
Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, São Paulo, Brazil.
Article Synopsis
- - The study investigates the effects of general inhalation anesthesia on pregnant mares during their last month of gestation, focusing on the impacts on both maternal and fetal health.
- - Nine mares were anesthetized for 90 minutes, revealing increased heart rate and arterial pressure, while also showing respiratory acidosis and a decrease in fetal heart rate.
- - Overall, despite significant hemodynamic changes during anesthesia, the results suggest that they do not negatively impact the short-term prognosis for the mother and fetus.
Increasing trends of laparoscopic procedures in non-obstetric surgery during pregnancy over 17 years at a single center: Retrospective case-control study.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Objective: This study aimed to examine the diseases requiring surgery during pregnancy, the changes in surgical methods over time, and the characteristics of surgeries performed in different trimesters.
Methods And Materials: A retrospective study conducted at Bundang CHA Hospital between 2006 and 2023 analyzed surgeries performed during pregnancy and compared laparoscopic and open approaches across the three trimesters of pregnancy. Additionally, general (appendicitis, cholecystitis) and gynecologic (heterotopic pregnancy, adnexal torsion) cases were compared.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!