Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486245 | PMC |
| http://dx.doi.org/10.1242/bio.059772 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways.
Arch Pharm Res
February 2024
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023, China.
Insulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated.
View Article and Find Full Text PDFPhosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.
Mol Med
August 2023
Department of Pediatrics, Cohen Children's Medical Center, Lake Success, NY, USA.
Article Synopsis
- Sepsis leads to an insulin-resistant state, but the specific impact on insulin signaling pathways, particularly through the phosphorylation of insulin receptors and substrate molecules, remains unclear.
- The hypothesis tested is that cecal ligation and puncture (CLP) would reduce the phosphorylation of insulin receptors IRβ and substrate molecules IRS-1 and IRS-2.
- Results show that while CLP did not significantly change the concentration of IRβ, IRS-1, or IRS-2 in muscles or liver, the phosphorylation levels of these molecules post-CLP at certain time points were similar to baseline levels, indicating that insulin signaling may be impaired during sepsis despite changes in concentration.
Erratum: IRS-1 regulates proliferation, invasion and metastasis of pancreatic cancer cells through MAPK and PI3K signaling pathways.
Int J Clin Exp Pathol
December 2022
Department of General Surgery, Shengjing Hospital Affiliated to China Medical University Shengyang, China.
[This corrects the article on p. 5185 in vol. 11, PMID: 31949598.
View Article and Find Full Text PDFCXCR4 mediates the effects of IGF-1R signaling in rodent bone homeostasis and fracture repair.
Bone
January 2023
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA; Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA. Electronic address:
Non-union fractures have considerable clinical and economic burdens and yet the underlying pathogenesis remains largely undetermined. The fracture healing process involves cellular differentiation, callus formation and remodeling, and implies the recruitment and differentiation of mesenchymal stem cells that are not fully characterized. C-X-C chemokine receptor 4 (CXCR4) and Insulin-like growth factor 1 receptor (IGF-1R) are expressed in the fracture callus, but their interactions still remain elusive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!