AI Article Synopsis
- Ancestral signaling pathways are crucial for development, physiology, and immunity in metazoans, highlighting the importance of interspecies communication.
- Researchers identified a tick receptor called Dome1 that has evolved to interact with the mammalian cytokine IFN-γ, activating the JAK-STAT pathway, which aids in tick feeding and development.
- The Dome1-JAK-STAT pathway, present in many Ixodid ticks, influences gut cell regeneration and metamorphosis through interactions with the Hedgehog and Notch-Delta networks, showcasing the evolutionary link between ticks and mammalian hosts.
Article Abstract
Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting vectorial competence. We highlight the evolutionary dependence of on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122270 | PMC |
| http://dx.doi.org/10.1126/science.abl3837 | DOI Listing |
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