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Antiviral and Immunomodulatory Effects of Zafirlukast Against Flaviviruses via Inhibition of the TNF Signaling Pathway.
J Med Virol
January 2025
Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia.
The two most clinically important members of the flavivirus genus, Zika virus (ZIKV) and dengue virus (DENV) pose a significant public health challenge. They cause a range of diseases in humans, from hemorrhagic to neurological manifestations, leading to economic and social burden worldwide. Nevertheless, there are no approved antiviral drugs to treat these infections.
View Article and Find Full Text PDFNew tools to monitor infection and biofilms in .
Front Cell Infect Microbiol
December 2024
School of Biosciences, University of Kent, Canterbury, United Kingdom.
Introduction: Antimicrobial resistance is a growing health problem. Pseudomonas aeruginosa is a pathogen of major concern because of its multidrug resistance and global threat, especially in health-care settings. The pathogenesis and drug resistance of depends on its ability to form biofilms, making infections chronic and untreatable as the biofilm protects against antibiotics and host immunity.
View Article and Find Full Text PDFInvestigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.
J Inflamm Res
December 2024
Department of Traumatology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 40014, People's Republic of China.
Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. PANoptosis, a unique inflammatory programmed cell death, it manifests as the simultaneous activation of signaling markers for pyroptosis, apoptosis, and necroptosis. However, research on the role of PANoptosis in the development of IPF is currently limited.
View Article and Find Full Text PDFAmeliorating Effects of β-Myrcene, a Monoterpene in Many Plants, on Thioacetamide-Induced Acute Hepatic Encephalopathy in Rats.
Arch Razi Inst
June 2024
Department of Pharmacy Practice, P.E.S. College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, India.
Hepatic encephalopathy (HE) is a clinical syndrome that can result from acute and chronic liver disorders, such as hepatitis, liver failure caused by alcohol or drugs, autoimmune diseases, metabolic diseases, cirrhosis, different types of tumors, and infections. This study aimed to investigate the effects of different doses of Beta-myrcene (β-myrcene) on the improvement of HE caused by thioacetamide (TAC) in male rats. To induce liver failure and acute damage in the studied animals, TAC was administered to rats at a dose of 100 mg/kg of body weight through an intraperitoneal (IP) injection with 24-hour intervals for seven consecutive days.
View Article and Find Full Text PDFAntinociceptive and anti-inflammatory activities of the methanol extract of Korovin in a rat model.
Arch Razi Inst
June 2024
Department of Pharmacy Practice, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan.
Today, the current chemical agents used for the management of pain cause numerous complications. They are associated with the occurrence of disorders in the digestive system, damage to the kidney, or addiction, which has prompted individuals to seek novel drugs that, apart from removing the side effects, are cost-effective and available. The present survey aimed to assess the antinociceptive and anti-inflammatory activity of Korovin methanolic extract (FEME) in male Swiss mice.
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