AI Article Synopsis
- A new colorimetric sensor array developed for the efficient detection and identification of proteins shows promise for use in medical diagnostics and treatment.
- This sensor works by exploiting how different osmolytes affect protein conformation and their binding to silver nanoparticles, resulting in distinct color changes for 19 different proteins.
- Additionally, the array is capable of analyzing protein mixtures and even biological samples, suggesting its ability to classify metabolic profiles based on dietary influences in salt-sensitive rats.
Article Abstract
Rapid and efficient detection and identification of proteins hold great promise in medical diagnostics, treatment of different diseases, and proteomics. Here, we present a simple colorimetric sensor array for the differentiation of proteins in various osmolyte solutions. Osmolytes have different influences on the conformation of proteins, which have differential binding to silver nanoparticles, resulting in color changes. The sensor array shows unique color change patterns for each of the 19 proteins, allowing unambiguous identification. Very interestingly, the differentiation of 19 proteins is related to their molecular weight. Moreover, the sensor array can be used to identify protein mixtures, thermal denaturized proteins, and unknown protein samples. Finally, the sensor array can also analyze the plasma or liver samples of the four groups of salt-sensitive rats fed with different diets, indicating that it has the potential for the classification of metabolic profiles.
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| http://dx.doi.org/10.1021/acssensors.2c01847 | DOI Listing |
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