Background And Objectives: Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the are responsible for a portion of this higher risk. We sought to assess the odds of AKI conferred by risk alleles in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Design, Setting, Participants, & Measurements: Black Americans who tested positive for coronavirus disease 2019 (COVID-19) were genotyped to determine risk allele status. We assessed the incidence of AKI, persistent AKI, and AKI requiring KRT within 21 days of the PCR-based diagnosis. Outcomes were adjusted for age, sex, body mass index, hypertension, eGFR, and use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker.
Results: In total, 126 cases of SARS-CoV-2 infection were included within a 5-month period, with 16 (13%) and 110 (87%) cases with two and zero/one high-risk alleles, respectively. AKI occurred in 11 (69%) patients with two high-risk alleles and 39 (35%) patients with zero/one high-risk alleles (adjusted odds ratio, 4.41; 95% confidence interval, 1.11 to 17.52; =0.04). Persistent AKI occurred in eight (50%) patients with two high-risk alleles and 21 (19%) of those with zero/one high-risk alleles (adjusted odds ratio, 3.53; 95% confidence interval, 1.8 to 11.57; =0.04). AKI KRT occurred in four (25%) of those with two high-risk alleles and eight (7%) of those with zero/one high-risk alleles (adjusted odds ratio, 4.99; 95% confidence interval, 1.02 to 24.4, =0.05).
Conclusions: high-risk alleles are associated with greater odds of AKI in Black American patients with COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729502 | PMC |
| http://dx.doi.org/10.2215/CJN.01070121 | DOI Listing |
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