Association between rs6493497 and rs936306 polymorphisms and depression susceptibility in the Chinese population.

The gene encodes the key aromatase for estrogen biosynthesis, and this study aimed to explore the relationship between rs6493497 and rs936306 polymorphisms and depression risk. rs6493497 and rs936306 genotyping was performed on 502 depression patients and 504 healthy controls. In the general population, no significant association was observed between the rs6493497 variant and depression, whereas that rs936306 variant significantly reduced depression risk in the recessive model. In subgroup analysis, a significant association of the rs6493497 variant with reduced depression risk was found in males aged 46-65 in the genotype, dominant and additive models. The rs936306 variant may reduce depression risk, and the rs6493497 variant is associated with decreased depression risk in males aged 46-65.