In response to the demographic change and the accompanying challenges for effective healthcare, approaches to enable using advancements of digitalization and IoT infrastructures as well as AI methods to deliver results in the field of personalized health assistance are necessary. In our research, we aim at enabling user-centered assistance with the help of networked sensors and Health Assistance Systems as well as learning methods based on connected graph data that model the shared system, user, and environmental context. In particular, this paper demonstrates a graph-based dynamic context model for a medication assistance system and presents an association rule learning method using Apriori algorithm to learn correlations between user vitals, activities as well as medication intake behavior. An application scenario for context-based heart rate monitoring is consequently presented as proof of concept, where associated contextual elements from the modeled context relating surges in monitored heart rate to environmental and user activity are shown.
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http://dx.doi.org/10.1016/j.artmed.2022.102455 | DOI Listing |
BMC Nephrol
January 2025
Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.
Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Department of Clinical Psychology and Psychotherapy, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Background: Unobtrusively collected objective sensor data from everyday devices like smartphones provide a novel paradigm to infer mental health symptoms. This process, called smart sensing, allows a fine-grained assessment of various features (eg, time spent at home based on the GPS sensor). Based on its prevalence and impact, depression is a promising target for smart sensing.
View Article and Find Full Text PDFPediatr Nephrol
January 2025
University of Western Ontario, London, ON, Canada.
Background: The 2023 IPNA guidelines recommended a 12-h mycophenolic acid (MPA) area under the curve (AUC) estimation for managing pediatric nephrotic syndrome and MPA AUC > 50 mg * h/L for an optimal therapeutic response to mycophenolate mofetil (MMF). The IPNA guidelines endorsed two limited AUC formulae based on three-point MPA measurements to predict 12-h MPA AUC. The relative performance of these two limited AUC formulae has not been tested.
View Article and Find Full Text PDFInt J Cardiol Cardiovasc Risk Prev
March 2025
Department of Cardiology, National University Heart Centre Singapore, Singapore.
Introduction: The severity of mitral stenosis (MS) is commonly assessed using mitral valve area (MVA) measured with transthoracic echocardiography (TTE). The dimensionless index (DI) of mitral valve (MV) was recently studied in degenerative MS. We evaluated DI MV in rheumatic MS and studied its relationship with clinical outcomes.
View Article and Find Full Text PDFContact (Thousand Oaks)
January 2025
Department of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, 28040 Madrid, Spain.
Microglia, the resident immune cells of the central nervous system (CNS), play a crucial role in maintaining tissue homeostasis by monitoring and responding to environmental changes through processes such as phagocytosis, cytokine production or synapse remodeling. Their dynamic nature and diverse functions are supported by the regulation of multiple metabolic pathways, enabling microglia to efficiently adapt to fluctuating signals. A key aspect of this regulation occurs at mitochondria-associated ER membranes (MAM), specialized contact sites between the ER and mitochondria.
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