AI Article Synopsis
- The study examines the link between contrast-induced nephropathy (CIN) and post-transcatheter aortic valve implantation (TAVI) mortality, highlighting the importance of predicting CIN risks.
- The modified Mehran score, which is calculated before the procedure, was found to be a significant predictor of CIN development compared to the original score.
- Among 171 TAVI patients, 25.7% experienced CIN, with high modified Mehran scores and elevated preoperative C-reactive protein levels identified as independent risk factors.
Article Abstract
Considering the increasing use of the transcatheter aortic valve implantation (TAVI) procedure, the relationship of contrast-induced nephropathy (CIN) with post-TAVI mortality has become important. The Mehran score was developed to detect the risk of CIN development after cardiac intervention. We aimed to compare the role of the modified Mehran score, which can be calculated pre-procedure, in predicting CIN development and compare it with the original Mehran score. We retrospectively collected data from TAVI procedures at our institution between December 2016 and June 2021; of 171 patients, 44 (25.7%) had CIN. We found no association between contrast media volume and CIN (387 ± 120 418 ± 139 mL, = .303). High and very high modified Mehran score and preoperative C-reactive protein (CRP) level were independent risk factors for CIN development after TAVI procedure. The area under curve (AUC) was .686 with 95% CI: .591-.780 and < .001, and also, with a cut-off point of >7.5 points, there was 79.5% sensitivity and 63.0% specificity; otherwise, with a cut-off point of >9.5 points, there was 54.5% sensitivity and 71.7% specificity, for the modified Mehran score. The modified Mehran score comes into prominence compared with the original Mehran score since it can be calculated pre-procedure.
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