The crystal structures of ()-(ethene-1,2-di-yl)bis-(di-phenyl-phosphine sulfide), CHPS (), along with its complex with Pt dichloride, di-chlorido[()-(ethene-1,2-di-yl)bis-(di-phenyl-phosphine sulfide)-κ ,']platinum(II), [PtCl(CHPS)] (), are described here. Compound features P=S bond lengths of 1.9571 (15) and 1.9529 (15) Å, with a torsion angle of 166.24 (7)° between the two phosphine sulfide groups. The crystal of compound features both intra-molecular C-H⋯S hydrogen bonds and π-π inter-actions. Mol-ecules of compound are held together with inter-molecular π-π and C-H⋯π inter-actions to form chains that run parallel to the -axis. The inter-molecular C-H⋯π inter-action has a H⋯ distance of 2.63 Å, a ⋯ distance of 3.573 (5) Å and a -H⋯ angle of 171° (where refers to the centroid of one of the phenyl rings). These chains are linked by relatively long C-H⋯S hydrogen bonds with ⋯ distances of 3.367 (4) and 3.394 (4) Å with -H⋯ angles of 113 and 115°. Compound features Pt-Cl and Pt-S bond lengths of 2.3226 (19) and 2.2712 (19) Å, with a P=S bond length of 2.012 (3) Å. The Pt center adopts a square-planar geometry, with Cl-Pt-Cl and S-Pt-S bond angles of 90.34 (10) and 97.19 (10)°, respectively. Mol-ecules of compound are linked in the crystal by inter-molecular C-H⋯Cl and C-H⋯S hydrogen bonds.
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http://dx.doi.org/10.1107/S2056989022011847 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
A spectacular diversity of forms and features allow species to thrive in different environments, yet some structures remain relatively unchanged. Insect compound eyes are easily recognizable despite dramatic differences in visual abilities across species. It is unknown whether distant insect species use similar or different mechanisms to pattern their eyes or what types of genetic changes produce diversity of form and function.
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January 2025
Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Binuclear silver(I) and copper(I) complexes, and , with bridging diphenylphosphine ligands were prepared. In , the silver(I) center is located inside a trigonal plane composed of three phosphorus donors from three separate and bridging dppm ligands. The fourth coordination site is filled with neighboring silver(I) ions.
View Article and Find Full Text PDFMol Divers
January 2025
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of Education, Jiangxi Province Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Identifying drug-target binding affinity (DTA) plays a critical role in early-stage drug discovery. Despite the availability of various existing methods, there are still two limitations. Firstly, sequence-based methods often extract features from fixed length protein sequences, requiring truncation or padding, which can result in information loss or the introduction of unwanted noise.
View Article and Find Full Text PDFEJNMMI Radiopharm Chem
January 2025
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Background: Poly (ADP-ribose) polymerase (PARP) enzymes are crucial for the repair of DNA single-strand breaks and have become key therapeutic targets in homologous recombination-deficient cancers, including prostate cancer. To enable non-invasive monitoring of PARP-1 expression, several PARP-1-targeting positron emission tomography (PET) tracers have been developed. Here, we aimed to preclinically investigate [carbonyl-C]DPQ as an alternative PARP-1 PET tracer as it features a strongly distinct chemotype compared to the frontrunners [F]FluorThanatrace and [F]PARPi.
View Article and Find Full Text PDFLangmuir
January 2025
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
The development of probes for the efficient detection of volatile organic compounds is crucial for both human health protection and environmental monitoring. In this study, we successfully synthesized a ratiometric fluorescent sensing material [Eu-UiO-67 (1:1)], featuring dual-emission fluorescence peaks via a one-pot method. This material demonstrated exceptional ratiometric fluorescence recognition properties for liquid styrene and isoprene, achieving low limit of detections (LODs) of 6.
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