AI Article Synopsis
- Only two antiangiogenic monoclonal antibodies combined with EGFR-TKIs (erlotinib + bevacizumab and erlotinib + ramucirumab) are currently approved for treating EGFR+ advanced non-small cell lung cancer.
- Patients eventually develop resistance to these treatments due to mechanisms like T790M substitutions and MET amplifications.
- Osimertinib is the only approved option for T790M+ patients, but emerging data suggests MET-TKIs and combinations with chemotherapy/immunotherapy could improve treatment strategies in the future.
Article Abstract
As of today, only two antiangiogenic monoclonal antibodies plus epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) combinations are FDA and EMA-approved and are recommended by American Society of Clinical Oncology, European Society for Medical Oncology, and National Comprehensive Cancer Network for the first-line treatment of EGFR+ advanced non-small cell lung cancer patients: erlotinib plus bevacizumab and erlotinib plus ramucirumab. However, all treated patients eventually become unresponsive to such drugs, due to several different acquired resistance mechanisms, mainly represented by T790M substitutions and MET amplifications. While osimertinib treatment in T790M+ patients still represents the only approved treatment, MET-TKIs will likely change this status quo in the near future. In fact, existing clinical data strongly support a role for MET-TKI-based combinations in EGFR+ MET-amplified patients, possibly revolutionizing our current treatment algorithm. Chemotherapy plus immunotherapy plus antiangiogenic therapy combinations could also represent another useful addition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771735 | PMC |
| http://dx.doi.org/10.20517/cdr.2022.77 | DOI Listing |
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