Purpose: Corneal collagen crosslinking (CXL) is an effective treatment for progressive keratoconus. Multiple CXL modalities are clinically available. The present study compared the 1 year outcomes of five types of CXL procedures for progressive keratoconus in a Chinese population using generalized estimating equations (GEE).
Methods: This retrospective study included 239 eyes in 171 patients with keratoconus who underwent CXL and were followed up for 1 year. Five CXL procedures were assessed, including Accelerated Transepithelial CXL, Iontophoresis CXL for 10 min, CXL plus phototherapeutic keratectomy (CXL-plus-PTK), High-Fluence Accelerated CXL, and Accelerated CXL. Patients treated with the Accelerated CXL procedure represented the reference group. Primary outcomes were visual acuity change, spherical equivalence, endothelial cell density, mean keratometry (K), maximum keratometry (K), minimum corneal thickness (MCT), and the ABCD Grading System, consisting of A (staging index for ARC; ARC = anterior radius of curvature), B (staging index for PRC, PRC = posterior radius of curvature), and C (staging index for MCT) values 1 year postoperatively compared to baseline. Secondary outcomes were corrected GEE comparisons from each procedure versus the Accelerated CXL group.
Results: The Accelerated Transepithelial CXL group had lower performance than the Accelerated CXL group according to K and K. The CXL-plus-PTK group performed significantly better than the reference group as reflected by K (β = -0.935, P = 0.03). However, the CXL-plus-PTK group did not perform as well for B and C, and the Iontophoresis CXL group performed better for C.
Conclusions: The CXL-plus-PTK procedure was more effective than the Accelerated CXL procedure based on K, and the Iontophoresis CXL procedure performed better on the C value based on the ABCD Grading System.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830808 | PMC |
| http://dx.doi.org/10.1186/s12886-022-02744-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corneal cross-linking.
Prog Retin Eye Res
December 2024
ELZA Institute, Webereistrasse 2, CH-8953, Dietikon, Switzerland; Laboratory for Ocular Cell Biology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206, Geneva, Switzerland. Electronic address:
First introduced over 20 years ago as a treatment for progressive keratoconus, the original "Dresden" corneal cross-linking (CXL) protocol involved riboflavin saturation of the stroma, followed by 30 min of 3 mW/cm-intensity ultraviolet-A (UV-A) irradiation. This procedure generates reactive oxygen species (ROS) that cross-link stromal molecules, thereby stiffening the cornea and counteracting the ectasia-induced weakening. Due to their large size, riboflavin molecules cannot readily pass through the corneal epithelial cell tight junctions; thus, epithelial debridement was performed.
View Article and Find Full Text PDFAim: To evaluate the long-term impact of accelerated corneal cross-linking (A-CXL) on selected refractive and topographical parameters in eyes with progressive keratoconus.
Methods: 77 eyes with keratoconus in 54 patients treated with A-CXL (10 min "epi-off" protocol) were included in the analysis. Preoperative and postoperative (1, 3 and 5 years after A-CXL) values of the studied parameters were compared.
EFFICACY OF TRANSEPITHELIAL ACCELERATED COLLAGEN CROSS LINKING IN STOPPING THE PROGRESSION OF KERATOCONUS.
J Ayub Med Coll Abbottabad
November 2024
Department of Ophthalmology, KMC/ Khyber Teaching Hospital Peshawar-Pakistan.
Background: Keratoconus is a progressive ectatic disease of the cornea leading to central corneal thinning, protrusion and permanent visual impairment in untreated cases. It is affecting young children with strong association to vernal keratoconjunctivitis a common disease of Asian countries. Corneal collagen cross linkage (CXL) is standard procedure to stop progression of keratoconus.
View Article and Find Full Text PDFElucidating synergistic effects during co-pyrolysis of plastics and paper in municipal solid waste: Thermal behavior and product characteristics.
Bioresour Technol
January 2025
Engineering Research Internal of Resource Utilization of Carbon-containing Waste with Carbon Neutrality, Ministry of Education, Shanghai 200237, PR China; Shanghai Engineering Research Internal of Coal Gasification, East China University of Science and Technology, Shanghai 200237, PR China.
Plastics and paper are common components of municipal solid waste (MSW), making an in-depth understanding of their interactions essential for MSW thermal conversion. In this study, the co-pyrolysis behavior of plastic and paper was investigated. Firstly, the thermal decomposition characteristics were analyzed.
View Article and Find Full Text PDFAccelerated versus conventional corneal collagen cross-linking for keratoconus: A meta-analysis of randomized controlled trials.
Eur J Ophthalmol
November 2024
Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan.
Purpose: To systematically compare the effectiveness of conventional corneal collagen cross-linking (CCXL) protocols and accelerated corneal collagen cross-linking (ACXL) protocols in cases with progressive keratoconus.
Methods: The Cochrane library, EMBASE, MEDLINE, PubMed, and Web of Science databases were searched for randomized controlled trials (RCTs). Outcomes were clinical results and changes in corneal properties.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!