Linkages between climate and human activity are often calibrated at daily or monthly resolutions, which lacks the granularity to observe intraday adaptation behaviors. Ignoring this adaptation margin could mischaracterize the health consequences of future climate change. Here, we construct an hourly outdoor leisure activity database using billions of cell phone location requests in 10,499 parks in 2017 all over China to investigate the within-day outdoor activity rhythm. We find that hourly temperatures above 30 °C and 35 °C depress outdoor leisure activities by 5% (95% confidence interval, CI 3-7%) and by 13% (95% CI 10-16%) respectively. This activity-depressing effect is larger than previous daily or monthly studies due to intraday activity substitution from noon and afternoon to morning and evening. Intraday adaptation is larger for locations and dates with time flexibility, for individuals more frequently exposed to heat, and for parks situated in urban areas. Such within-day adaptation substantially reduces heat exposure, yet it also delays the active time at night by about half an hour, with potential side effect on sleep quality. Combining empirical estimates with outputs from downscaled climate models, we show that unmitigated climate change will generate sizable activity-depressing and activity-delaying effects in summer when projected on an hourly resolution. Our findings call for more attention in leveraging real-time activity data to understand intraday adaptation behaviors and their associated health consequences in climate change research.
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http://dx.doi.org/10.1038/s41598-022-26928-y | DOI Listing |
Quant Finance
September 2024
Oxford-Man Institute of Quantitative Finance, University of Oxford, Oxford, UK.
Volatility forecasts play a central role among equity risk measures. Besides traditional statistical models, modern forecasting techniques based on machine learning can be employed when treating volatility as a univariate, daily time-series. Moreover, econometric studies have shown that increasing the number of daily observations with high-frequency intraday data helps to improve volatility predictions.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
October 2024
Department of Forensic Medicine and Toxicology, Faculty of Medicine, School of Health Sciences, University of Ioannina, University Campus, Ioannina 45500, Greece; University Hospital of Ioannina, Ioannina 45110, Greece. Electronic address:
Liquid chromatography coupled with mass spectrometry (LC-MS) has been tremendously used for screening purposes in forensic toxicology, because of their great adaptability and reasonable time/resource consumption. Herein, a fully validated method based on liquid-liquid extraction (LLE) in human whole blood, by a multiple reaction monitoring (MRM) analysis through LC-MS/MS, is described. The proposed method simultaneously detects 100 analytes (plus three deuterated internal standard compounds) belonging to many different classes, including drugs of abuse, prescription and over-the-counter drugs commonly involved in poisoning and medical malpractice cases in our territory, as well as certain new psychoactive substances (NPS) and toxic substances potentially associated with adverse effects.
View Article and Find Full Text PDFDrug Metab Bioanal Lett
July 2024
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, (Deemed to be University), Vile Parle West, Mumbai, Maharashtra, 400056, India.
Background: Eltrombopag Olamine is a drug used to treat thrombocytopenia, a disorder where blood platelet counts get lower and severe aplastic anemia. It serves as a thrombopoietin receptor agonist, which give rise to platelet production in the bone marrow.
Objectives: The objective of this study is to develop a simple, specific, accurate, precise and economical Ultraviolet spectroscopy method to estimate the amount of Eltrombopag Olamine in bulk and tablet dosage form.
Environ Int
May 2024
Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address:
Int J Biometeorol
August 2024
Department of Geography, University of Barcelona, Montalegre 6, Barcelona, 08001, Spain.
The availability of reliable information on local climatic-tourism conditions is a growing need due to the influence it exerts on the quality of the organizational strategy of tourist destination's, and travel experience. Evaluations of the tourism potential of the climate have been carried out on a daily or monthly resolution, thus limiting the collection of detailed information that makes it possible to fine-tune tourism management and operational decision-making on an intraday scale. This research is the first case study to analyse the climatic suitability for nature tourism, using the weather types method at hourly resolution.
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