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A rare case of Whipple disease presenting as a hydrosalpinx and granulomatous peritonitis.
J Infect Dev Ctries
August 2024
Department for Gastroenterology, Military Medical Academy, Belgrade, Serbia.
Article Synopsis
- Whipple disease, caused by the bacterium Tropheryma whipplei, is a rare infection that primarily impacts the gastrointestinal and musculoskeletal systems but can also affect the heart, brain, and lungs, making diagnosis difficult due to varied symptoms.
- A case study of a young woman revealed miliary lesions in the pelvis during laparoscopy, initially leading to a diagnosis of granulomatous salpingitis and peritonitis, but ultimately, Tropheryma whipplei was identified as the cause.
- Timely and appropriate antibiotic treatment is crucial for a positive outcome in Whipple disease, emphasizing the need for increased awareness among healthcare professionals.
Subtle Sonographic Signs of Disseminated Tuberculosis: A Case Report and Narrative Literature Review.
Am J Trop Med Hyg
September 2024
Lighthouse Clinic Trust, Lilongwe, Malawi.
Miliary tuberculosis is a form of disseminated tuberculosis that can be difficult to detect when the classic pattern is absent on chest radiograph and advanced cross-sectional imaging is not readily available. While the focused assessment with sonography for HIV-associated tuberculosis (FASH) protocol for extrapulmonary tuberculosis emphasizes easy-to-teach findings, experienced sonographers may detect additional, subtler signs that can aid in diagnosis. We report a case of a 20-year-old man with miliary tuberculosis diagnosed on computed tomography of the chest.
View Article and Find Full Text PDFThe role of multimodality imaging in the selection and management of patients treated with cytoreductive surgery and HIPEC.
Abdom Radiol (NY)
December 2024
The Christie NHS Foundation Trust, Manchester, UK.
Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is the mainstay of potentially curative surgical treatment for malignancies that have spread to peritoneal surfaces. This surgical procedure is however associated with high morbidity and appropriate patient selection and planning is therefore essential. Available multimodality imaging techniques include CT with oral and intravenous contrast, MRI including use of dedicated peritoneal protocol and FDG-PET/CT.
View Article and Find Full Text PDFPrediction of nonresectability using the updated Predictive Index value model assessed by imaging and surgery in tubo-ovarian cancer: a prospective multicenter ISAAC study.
Am J Obstet Gynecol
December 2024
Department of Gynecology, Obstetrics and Neonatology, First Faculty of Medicine, Gynecologic Oncology Centre, Charles University and General University Hospital in Prague, Prague, Czech Republic. Electronic address:
Background: A laparoscopy-based scoring system was developed by Fagotti et al (Fagotti or Predictive Index value (PIV)score) based on the intraoperative presence or absence of carcinomatosis on predefined sites. Later, the authors updated the PIV score calculated only in the absence of one or both absolute criteria of nonresectability (mesenteric retraction and miliary carcinomatosis of the small bowel) (updated PIV model).
Objective: The aim was to demonstrate the noninferiority of ultrasound to other imaging methods (contrast enhanced computed tomography (CT) and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI)/MRI) in predicting nonresectable tumor (defined as residual disease >1 cm) using the updated PIV model in patients with tubo-ovarian cancer.
Stratification of Homologous Recombination Deficiency-Negative High-Grade Ovarian Cancer by the Type of Peritoneal Spread into Two Groups with Distinct Survival Outcomes.
Cancers (Basel)
June 2024
Department of Obstetrics and Gynecology, Medical University Innsbruck, 6020 Innsbruck, Austria.
Background: Homologous recombination deficiency (HRD) has evolved into a major diagnostic marker in high-grade ovarian cancer (HGOC), predicting the response to poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) and also platinum-based therapy. In addition to HRD, the type of peritoneal tumor spread influences the treatment response and patient survival; miliary type tumor spread has a poorer predicted outcome than non-miliary type tumor spread.
Methods: Known methods for HRD assessment were adapted for our technical requirements and the predictive-value integrated genomic instability score (PIGIS) for HRD assessment evolved as an outcome.
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