AI Article Synopsis
- Invasive meningococcal disease (IMD) is on the rise, especially post-COVID-19, due to decreased vaccination rates and relaxed health measures.
- Researchers analyzed six Neisseria meningitidis serogroup X isolates from Brazil over three decades using whole-genome sequencing, discovering a major lineage.
- The study highlights the presence of the ST2888 lineage in Brazil and emphasizes the need for continuous monitoring to prevent non-vaccine preventable IMD cases.
Article Abstract
Introduction: Invasive meningococcal disease (IMD) is a major health problem. Given the post-COVID-19 pandemic scenario with the loosening of the non-pharmacological measures to control the virus transmission and considering the observed global reduction of meningococcal vaccination coverage, an increase in IMD cases can be expected.
Methodology: Using whole-genome sequencing, we characterized six Neisseria meningitidis serogroup X (MenX) isolates recovered from IMD cases in Brazil in the last 30 years.
Results: The predominance (66.6%, 4/6) of ST2888 presenting fHbp 160, NHBA 129, NadA 21, and PorA 19,15 was found on isolates. Two novel STs, 15458 and 15477, were described.
Conclusion: This study describes the circulation of MenX lineage ST2888 in Brazil, previously reported only in Europe. Continuous universal surveillance is crucial to implement prompt public health measures aiming to prevent and control non-vaccine preventable serogroup X IMD cases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838296 | PMC |
| http://dx.doi.org/10.1007/s10123-023-00325-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!