AI Article Synopsis
- As survival rates for extremely preterm infants improve, the incidence of bronchopulmonary dysplasia (BPD), a major complication, is rising due to multiple stress factors.
- BPD can lead to serious short-term and long-term health issues, including problems with breathing, heart function, and neurological development.
- Transforming growth factor β (TGF-β) plays a key role in lung development and is linked to BPD; this review explores how it interacts with risk factors and current or developing medications aimed at preventing or treating BPD.
Article Abstract
As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor β (TGF-β) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-β in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-β signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-β signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988523 | PMC |
| http://dx.doi.org/10.1152/ajplung.00106.2021 | DOI Listing |
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