AI Article Synopsis
- A 40-year-old Japanese man diagnosed with HIV at 29 developed Graves' disease at 35 and slowly progressive type 1 diabetes at 38, indicating an autoimmune response.
- After starting antiretroviral treatment, tests showed that the autoimmune antibodies related to his conditions were positively correlated, suggesting that both diseases may have emerged due to the immune-inflammatory reconstitution syndrome.
Article Abstract
Patients with human immunodeficiency virus (HIV) infection receiving antiretroviral therapy can develop autoimmune diseases, referred to as immune-inflammatory reconstitution syndrome. Nevertheless, only a few reports on the onset of type 1 diabetes as immune-inflammatory reconstitution syndrome are available. A 40-year-old Japanese man with HIV infection was initiated with antiretroviral therapy at the age of 29 years. He developed Graves' disease at 35 years and diabetes, with a hemoglobin A1c of 6.5%, and maintained insulin secretion at 38 years. His antiglutamic acid decarboxylase antibody level was >2,000 U/mL, and he was diagnosed with slowly progressive type 1 diabetes. At the age of 40 years, he was admitted to our hospital with diabetic ketosis. We retrospectively assayed his stored plasma samples for thyroid-stimulating hormone receptor antibody and antiglutamic acid decarboxylase antibody, which showed positive conversion after initiating antiretroviral therapy, suggesting that Graves' disease and type 1 diabetes developed as a probable result of immune-inflammatory reconstitution syndrome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951569 | PMC |
| http://dx.doi.org/10.1111/jdi.13965 | DOI Listing |
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