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Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).
Function (Oxf)
July 2024
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Article Synopsis
- Regular physical activity is essential for overall health, but understanding how endurance exercise affects molecular signaling is still a work in progress.
- The MoTrPAC project aims to explore these molecular responses by conducting structured endurance training on Fischer 344 rats of different ages and sexes, analyzing various tissues and other biological samples.
- The study found significant improvements in muscle function and fitness markers within just a few weeks of exercise, highlighting age- and sex-related differences and providing valuable resources for future research on exercise responses.
Article Synopsis
- Regular exercise is really good for our whole body and helps stop diseases, but scientists are still figuring out exactly how it works at a tiny level.
- A group of researchers studied how endurance exercise affected the bodies of rats over eight weeks, looking at lots of different biological factors in blood and tissues.
- They found many important changes in the rat's bodies that can help us understand how exercise benefits human health—like how it relates to liver health, heart health, and recovery from injuries!
The impact of exercise on gene regulation in association with complex trait genetics.
Nat Commun
May 2024
Stanford University, Stanford, CA, USA.
Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes.
View Article and Find Full Text PDFRichard Jackson-Be empathetic, humble, and clear.
Risk Anal
November 2022
Consortium for Risk Evaluation with Stakeholder Participation (CRESP), Rutgers University, Piscataway, New Jersey, USA.
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