Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia.
Cells
November 2024
Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fibromyalgia (FM) is a chronic and debilitating condition characterized by diffuse pain, often associated with symptoms such as fatigue, cognitive disturbances, and mood disorders. Metformin, an oral hypoglycemic agent, has recently gained attention for its potential benefits beyond glucose regulation. It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic pain conditions like FM.
View Article and Find Full Text PDFExploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone in mice.
Behav Brain Res
March 2025
Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS 96010-900, Brazil. Electronic address:
1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone (ETAP) is a novel hybrid compound containing 1,2,3-triazole and acetophenone. It exhibits antidepressant-like effects in male mice, linked to modulation of serotonergic receptors and monoamine oxidase A (MAO-A) inhibition. This study aimed to evaluate the involvement of the dopaminergic and noradrenergic systems, as well as MAO-B activity inhibition, in the antidepressant-like effect of ETAP in male mice, and to evaluate the antidepressant-like effect of ETAP in female mice.
View Article and Find Full Text PDFImpact of yohimbine on myoglobin stability: insights from molecular spectroscopic, and computational approaches.
J Biomol Struct Dyn
November 2024
Department of Chemistry, National Institute of Technology Nagaland, Dimapur, Nagaland, India.
Article Synopsis
- The study focuses on the interaction between the bioactive ligand yohimbine (Yoh) and the protein myoglobin (Mb), highlighting its importance in pharmacokinetics and pharmacodynamics.
- Through emission spectroscopy, it was found that Yoh has a binding constant of 10 M and a 1:1 binding site ratio with Mb, while structural changes in Mb were observed using circular dichroism.
- The validation of binding interactions was supported by molecular dynamics simulations, showing that the Mb-Yoh complex remains stable over time, which is crucial for understanding drug design and bioavailability.
An antagonist of the neurotransmitter tyramine inhibits the hyperactivating effect of eugenol in the blood-sucking bug, Triatoma infestans.
Acta Trop
December 2024
Centro de Investigaciones de Plagas e Insecticidas (UNIDEF-CITEDEF-CONICET-CIPEIN y Ministerio de Defensa), Juan B. de La Salle 4397, (B1603ALO) Villa Martelli, Buenos Aires, Argentina; Instituto de Investigación e Ingeniería Ambiental, Universidad Nacional de San Martín (UNSAM), (B1650HMQ) San Martín, Buenos Aires, Argentina.
Eugenol is a botanical monoterpene found in the essential oils of several aromatic plants. It has shown to have insecticidal activity, modify insect behavior, and its site of action is most probably in the octopaminergic system. The aim of the present study was to explore whether tyramine receptors are involved in the hyperactivity produced by eugenol in Triatoma infestans, one of the main vectors of Chagas disease.
View Article and Find Full Text PDFand parthenolide increase defensive agents and promote antisecretory activity supporting their gastroprotective actions in rodents.
Nat Prod Res
November 2024
Postgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, Santa Catarina, Brazil.
Article Synopsis
- The study investigates the anti-ulcer effects of hydroalcoholic extract (HETp) and its active component parthenolide (PTL) against gastric ulcers induced by ethanol and piroxicam.
- Results showed that both HETp and PTL significantly reduced ulcer formation, with additional histological support confirming their effectiveness.
- The protective effects involve various mechanisms, including the influence of nitric oxide, adrenergic receptors, and prostaglandins, while also enhancing antioxidant levels and reducing harmful enzyme activity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!