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Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides.
Nat Prod Rep
December 2024
Fundación MEDINA, Avda Conocimiento 34, 18016 Granada, Spain.
Covering: up to 2024Fungal pathogens are a major threat to public health, with emerging resistance to all three classes of antifungals that are currently available and increased incidence of invasive fungal infections among hospitalized patients. Ibrexafungerp is a semi-synthetic analog of enfumafungin and the first antifungal agent approved in more than 20 years since the launch of caspofungin, the first of echinocandins. This new drug approval was made possible after a long arduous journey lasting 25 years by dedicated and talented medicinal chemists from two companies that undertook tedious atom-by-atom chemical modification of the natural product enfumafungin, a glycosylated fernane-type triterpenoid isolated from the fungus .
View Article and Find Full Text PDFDriving Deployment of Bioengineered Products-An Arduous, Sometimes Tedious, Challenging, Rewarding, Most Exciting Journey That Has to Be Made!
Bioengineering (Basel)
August 2024
Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia.
More than three decades ago, we embarked on a number of bioengineering explorations using the most advanced materials and fabrication methods. In every area we ventured into, it was our intention to ensure fundamental discoveries were deployed into the clinic to benefit patients. When we embarked on this journey, we did so without a road map, not even a compass, and so the path was arduous, sometimes tedious.
View Article and Find Full Text PDFJourney Through Healthcare of People With Complications of Type 2 Diabetes: A Qualitative Study of Lived Experiences.
Int J Integr Care
May 2024
Antwerp University, Faculty of Medicine and Health Sciences, Department of Family Medicine and Population Health, Antwerp, Belgium.
Article Synopsis
- The Belgium healthcare system has good overall performance but struggles with equal access, leading to late diagnoses and complications for low-income individuals with chronic diseases like type 2 diabetes.
- This study utilized interviews with individuals facing advanced diabetes to understand their care experiences and found that most were diagnosed late, with varying treatment and provider experiences.
- Key issues identified include the high non-medical costs of care, the need for better diabetes screening, the importance of recognizing paramedical roles, and the necessity for improved financial support and patient education.
Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic.
J Pharmacol Exp Ther
January 2024
Department of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, Texas and Institute of Pharmacology and Neurotherapeutics, Texas A&M University Health Science Center, Bryan, Texas
Article Synopsis
- The article discusses the potential of neurosteroids, specifically ganaxolone (GX), as new anticonvulsants for treating refractory status epilepticus (RSE) and as countermeasures for organophosphate nerve agents.
- Despite the approval of some benzodiazepines for acute seizures, there remains an urgent need for more effective treatments for RSE and nerve agent-related seizures.
- Recent findings show that neurosteroids like GX can rapidly control seizures and provide neuroprotection, leading to better neurological outcomes, paving the way for advanced clinical trials and further research to develop these treatments.
Motivations and challenges of Israeli nurses on their journey to a PhD: A qualitative study.
Nurse Educ Pract
March 2023
Nursing Department, Ashkelon Academic College, Israel. Electronic address:
Aim: This qualitative study aimed to examine the motivations and challenges encountered by Israeli nurses during their journey to achieve a doctoral degree (PhD).
Background: The increasing numbers of nurses studying for a doctoral degree may contribute to improving nursing education, expanding the body of knowledge and promoting the status of nursing as a research profession. However, many countries have reported a shortage in nurses with doctoral degrees.
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