AI Article Synopsis
- - mt-sDNA testing is a stool-based method for screening colorectal cancer (CRC), showing that in an initial test, 16% were positive with a positive predictive value (PPV) of 27.3% for cancer or advanced lesions
- - A study reviewed data from 2758 patients who took a second test after a negative first result, finding a 15% positivity rate and PPV of 0.25% for CRC, 24% for advanced lesions, and 67% for any colorectal growth
- - The findings indicate that the test's performance was consistent between the first and second screenings, supporting the relevance of conducting a second mt-sDNA test for CRC detection effectiveness
Article Abstract
Background & Aims: Multitarget stool DNA (mt-sDNA) testing is a stool-based screening test for colorectal cancer (CRC). In a single instance of testing, the pivotal Food and Drug Administration-approval study (NCT01397747) found that 16% of mt-sDNA tests were positive, and the positive predictive value (PPV) for CRC or advanced precursor lesions (APL) was 27.3%. We aimed to examine real-world longitudinal performance by determining the test-positive rate and PPV of mt-sDNA on the second round of testing.
Methods: Colonoscopy and pathology reports were reviewed retrospectively for patients with a negative mt-sDNA on the first round of screening and a positive mt-sDNA on the second round. The test-positivity rate and PPV for CRC, APL, and any colorectal neoplasia were calculated for the second mt-sDNA and compared with baseline PPVs from a previously published cohort of patients from our institution who tested positive on the first round of screening.
Results: A total of 2758 patients completed a second test at a median of 3.2 years after the first test. Of these, 422 (15%) had a positive second mt-sDNA. The PPV was 0.25% for CRC, 24% for APL, and 67% for any colorectal neoplasia. There was no significant difference in PPV on the second mt-sDNA test compared with the first round (24% vs 28% for APL; P = .12).
Conclusions: mt-sDNA test positive rate and PPV were similar between the first and second rounds of screening. These observations confirm the utility of a second round of mt-sDNA screening and may inform estimates of mt-sDNA effectiveness for CRC screening.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323033 | PMC |
| http://dx.doi.org/10.1016/j.cgh.2022.12.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Complexity Control in Artificial Self-Organizing Systems: The Case of Bottom-Up versus Top-Down Intervention When Managing Pandemic Contagion.
Nonlinear Dynamics Psychol Life Sci
January 2025
Adelphi University, Garden City, NY.
We model an adaptive agent-based environment using selfish algorithm agents (SA-agents) that make decisions along three choice dimensions as they play the multi-round prisoner's dilemma game. The dynamics that emerge from mutual interactions among the SA-agents exhibit two collective-level properties that mirror living systems, thus making these models suitable for societal/biological simulation. The properties are: emergent intelligence and collective agency.
View Article and Find Full Text PDFEfficient removal of direct dyes and heavy metal ion by sodium alginate-based hydrogel microspheres: Equilibrium isotherms, kinetics and regeneration performance study.
Int J Biol Macromol
January 2025
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China; Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266100, China; Key Laboratory of Ocean Observation and Information of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya 572024, China. Electronic address:
Improving the adsorption capacity of materials for pollutants by means of modification is an important direction in the research of water treatment technology. To improve the applicability of sodium alginate composites in the field of adsorption, magnetic sodium alginate-based hydrogel microsphere adsorbent material FeO@SA/PEI-Fe (FSPF) was synthesized in a single step by using polyethyleneimine grafting modification of sodium alginate by sol-gel method. The material was used for the removal of direct blue GL (DB 200) and direct date red B (DR 13) from simulated wastewater, as well as Cu(II) and Pb(II) from simulated wastewater with heavy metal ions.
View Article and Find Full Text PDFDevelopment, Validation, and Usability of a Virtual Game for Consciousness and Relaxation of the Pelvic Floor Muscles.
Neurourol Urodyn
January 2025
Department of Physical Therapy, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Background: Applicability of the virtual games has been increasingly added to rehabilitation treatments, including women's health interventions.
Objective: To develop a virtual interface designed to increase consciousness and relax the pelvic floor muscles, validate its content and appearance, and check the level of usability and satisfaction.
Methods: Physiotherapy specialists with experience in pelvic floor rehabilitation and database research were consulted to define the content.
European consensus on endoscopic surgery for bilateral vocal fold immobility: classification and nomenclature.
Eur Arch Otorhinolaryngol
January 2025
Department of Otolaryngology and Phoniatrics-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Introduction: There are inconsistencies in how different endoscopic procedures to manage Bilateral Vocal Fold Immobility (BVFI) have been described in the literature. This limits our ability to compare functional outcomes. There is no unifying international terminology available that precisely describes the anatomical boundaries and extent of the different types of treatment.
View Article and Find Full Text PDFNon-uniform failure mechanism and stability control of mining roadway under deviatoric stress field.
Sci Rep
January 2025
Institute of Mine Safety Technology, China Academy of Safety Science and Technology, Beijing, 100012, China.
Based on the elastic-plastic theory, the analytical formula of the second invariant J of deviatoric stress at any point around the circular roadway under the non-uniform stress field is derived. The distribution law of J of surrounding rock under the three-dimensional non-isobaric stress field is studied by theoretical analysis and numerical simulation. Combined with the butterfly failure theory of surrounding rock of roadway, the close relationship between the distribution pattern of J and the distribution pattern of plastic zone is found, and the failure mechanism of surrounding rock is revealed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!