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Convergent Synthesis, Kinetics, and Computational Studies of Indole(Phenyl)Triazole Bi-Heterocycles Modified With Propanamides as Elastase Inhibitors.
Chem Biodivers
November 2024
Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Chungnam, South Korea.
Biological screening combined with the synthesis of heterocyclic compounds with numerous functions is the most effective approach available for pharmacological assessment of potential future medications. In the under taken research that is presented here, 4-(1H-indol-3-yl)butanoic acid was sequentially converted into 4-(1H-indol-3-yl)butanoate, 4-(1H-indol-3-yl)butanohydrazide, and 5-[3-(1H-indol-3-yl)propyl]-1,2,4-triazole-2-thiol as a nucleophile. By treating aryl amines with 3-bromopropanoyl chloride in a series of parallel reactions, different electrophiles were created, leading to the formation of N-(aryl)-3-bromopropanamides.
View Article and Find Full Text PDFStereotactic Body Radiation Therapy for Primary Renal Cell Carcinoma: A Case-Based Radiosurgery Society Practice Guide.
Pract Radiat Oncol
July 2024
Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Center, University of Melbourne, Melbourne, Victoria, Australia.
Article Synopsis
- Recent studies show that stereotactic body radiation therapy (SBRT) can effectively treat renal cell carcinoma (RCC), a type of kidney cancer once thought to be resistant to radiation.
- The article emphasizes the importance of practical guidelines for patient selection and treatment planning, particularly for complex cases like solitary kidneys or large tumors.
- The guide, supported by the Radiosurgery Society, includes case studies and discusses key aspects such as tumor size, radiation dosages, and advanced imaging techniques for assessing treatment response.
[A Case of Conversion Surgery for Stage Ⅳ ATP-Producing Gastric Cancer with Distant Metastasis].
Gan To Kagaku Ryoho
March 2024
Dept. of Surgery, Kansai Rosai Hospital.
We report a case in which a patient with advanced gastric cancer with liver metastasis and bulky N showed marked tumor shrinkage with chemotherapy, and underwent conversion surgery. A 77-year-old male. Patient was referred to our department because of advanced gastric cancer.
View Article and Find Full Text PDFGlottic Neurofibroma: An Unusual Case Report.
Indian J Otolaryngol Head Neck Surg
June 2023
Bombay Hospital Voice and Swallowing Centre, Bombay Hospital and Medical Research Centre, 2nd Floor MRC, Mumbai, Maharashtra 400020 India.
Solitary neurofibromas of the larynx occur sporadically and usually tend to involve the aryepiglottic folds. Non-plexiform variants of neurofibromas involving the glottis are extremely rare and may have defined margins versus plexiform subtype which are often unencapsulated and associated with Von Recklinghausen's disease. We report an unusual case of isolated glottic neurofibroma in an elderly male with gradually progressive hoarseness of voice with stroboscopy findings of a right unilateral, bulky subepithelial lesion mimicking a vocal fold cyst.
View Article and Find Full Text PDFBulky, Solitary Hepatocellular Carcinoma.
Int J Radiat Oncol Biol Phys
February 2023
Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Sidney Kimmel Cancer Center, Baltimore, Maryland.
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