Objectives: Melancholic depression may respond differently to certain treatments. The aim of this study was to compare the antianhedonic effects of six intravenous injections of 0.5 mg/kg ketamine in patients with melancholic and non-melancholic depression, which remain largely unknown.
Methods: Individuals experiencing melancholic ( = 30) and non-melancholic ( = 105) depression were recruited and assessed for anhedonic symptoms using the Montgomery-Åsberg Depression Rating Scale (MADRS). The presence of melancholic depression was measured with the depression scale items at baseline based on DSM-5 criteria.
Results: A total of 30 (22.2%) patients with depression fulfilled the DSM-5 criteria for melancholic depression. Patients with melancholic depression had a non-significant lower antianhedonic response (43.3 vs. 50.5%, = 0.5, > 0.05) and remission (20.0 vs. 21.0%, = 0.01, > 0.05) to repeated-dose ketamine infusions than those with non-melancholic depression. The melancholic group had significantly lower MADRS anhedonia subscale scores than the non-melancholic group at day 26 ( < 0.05).
Conclusion: After six ketamine infusions, the improvement of anhedonic symptoms was found in both patients with melancholic and non-melancholic depression, and the efficacy was similar in both groups.
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| http://dx.doi.org/10.3389/fpsyt.2022.1033019 | DOI Listing |
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Article Synopsis
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- The study involved 40 melancholic MDD patients, 40 non-melancholic MDD patients, and 50 healthy controls participating in tasks measuring brain responses (ERPs) related to social rewards.
- Findings suggest that altered social reward processing could be a potential biomarker for melancholic depression, highlighting the specific neurophysiological differences in reward perception among those affected.
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