Objective: Our study aimed to evaluate the influence of methylenetetrahydrofolate reductase () polymorphism on the clinical features and therapeutic effects in patients with migraine.

Methods: The data of 135 patients with migraine were collected from January 2021 to December 2021. The C677T polymorphism was analyzed. The pain intensity was evaluated using a numerical rating scale (NRS) during treatment. The levels of folic acid, homocysteine (Hcy), vitamin B12, interleukin-2 (IL-2), IL-4, and ferritin, and changes of NRS were compared between folic acid and conventional treatment groups stratified by different genotypes of in migraine patients.

Results: The levels of Hcy and ferritin in male patients were higher than that in female patients ( < 0.05); Compared with CC and CT genotype groups, the TT genotype group showed significantly higher Hcy levels ( < 0.05) and lower folic acid levels ( < 0.05); In both folic acid and conventional treatment groups, a significant decrease in NRS score was observed in different genotypes post-treatment ( < 0.05). Patients with TT genotype in the folic acid treatment group showed better therapeutic efficacy than conventional treatment group ( < 0.05). There is no significant difference in the therapeutic efficacy in other genotypes between the two groups ( > 0.05).

Conclusion: The C677T genotyping may provide a new method to guide and optimize individualized medication for migraine patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816401PMC
http://dx.doi.org/10.3389/fneur.2022.1074857DOI Listing

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