Exercise plays a beneficial regulating role on each organ of the body through different mechanisms and is a powerful weapon to prevent disease. Irisin is released from muscle and widely distributed in the human body, participating in the physiological processes of multiple human systems and playing a protective role in multiple human organs. The protective effect of irisin on the nervous system is particularly remarkable, which can improve cognitive function, reduce the risk of ischemic stroke and improve its prognosis. Irisin also plays a guiding role in the prevention and treatment of neurodegenerative diseases and ischemic cerebrovascular diseases. Exercise is the driving factor promoting irisin secretion, and different exercise modes, intensity, frequency, and time all affect the level of serum irisin. As a result of analyzing the effects of various exercise modes on irisin secretion, we proposed an exercise program with a higher level of irisin secretion.
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| http://dx.doi.org/10.1016/j.heliyon.2022.e12352 | DOI Listing |
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Serum Irisin Levels Are Positively Correlated with Physical Activity Capacity in Hemodialysis Patients.
Kidney Blood Press Res
January 2025
Introduction: Regular physical activity is beneficial for health but is often reduced in patients receiving maintenance hemodialysis treatment. Irisin is a muscle-secreted hormone that reportedly improves metabolism and slows down the progression of some chronic diseases. In this study, we aimed to investigate the relationship between physical activity capacity and serum irisin levels in hemodialysis patients.
View Article and Find Full Text PDFRelationship of serum irisin levels, physical activity, and metabolic syndrome biomarkers in obese individuals with low-calorie intake and non-obese individuals with high-calorie intake.
J Health Popul Nutr
January 2025
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Article Synopsis
- The study examined how serum irisin levels relate to physical activity and metabolic health among obese individuals with low-calorie diets compared to non-obese individuals with high-calorie diets.
- Obese participants showed significantly lower physical activity levels than non-obese participants, but irisin levels were similar in both groups.
- A positive association was found between irisin levels and body composition metrics like total body water and lean body mass in the non-obese group, suggesting different metabolic responses to exercise and nutrition between the groups.
Circulating irisin levels in patients with MAFLD: an updated systematic review and meta-analysis.
Front Endocrinol (Lausanne)
January 2025
Department of Infectious Diseases, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Article Synopsis
- This systematic review and meta-analysis investigates the connection between circulating irisin levels and metabolic dysfunction-associated fatty liver disease (MAFLD), finding significantly lower irisin levels in MAFLD patients compared to healthy individuals.
- The study included data from 15 case-control studies and highlighted that lower irisin levels were particularly evident in specific populations, such as Asians and individuals over 50, while also showing notable differences based on the severity of the disease and the presence of Type 2 Diabetes (T2DM).
- Overall, the findings reinforce the association between circulating irisin and the progression of MAFLD, despite differences from previous research results.
Relation of serum irisin levels with adiposity, components of metabolic syndrome and carotid intima media thickness in prepubertal children with obesity: a cross-sectional study.
Endocrine
December 2024
Diabetes & Metabolism Clinic, 2nd Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, Athens, Greece.
Aim: Irisin, a newly discovered adipomyokine, has pleiotropic effects in metabolic and energy homeostasis, insulin resistance (IR), and browning of white adipose tissue. The aim of this study was to evaluate irisin levels in children with obesity and also to elucidate possible relationships between irisin with anthropometric obesity indices, parameters of metabolic syndrome (MetS), and intima media thickness (IMT).
Methods: A total of 77 prepubertal children, 4-12 years old, were enrolled in this study, including 44 children with obesity (BMI ≥ 95th percentile) and 33 normal weight controls of matched age and gender.
Acute effect of exercise on appetite-related factors in males with obesity: A pilot study.
Physiol Rep
December 2024
Department of Exercise Physiology, University of Guilan, Guilan, Iran.
To investigate the role of appetite-related factors, including interleukin 6 (IL-6), irisin, interleukin 7 (IL-7), neuropeptide Y (NPY), and leptin, on appetite perception in males with obesity. Eleven males (BMI 35.3 ± 4.
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