Transformative changes are needed in the transport sector to limit global warming. Radical transport disruptions experienced during the COVID-19 pandemic, such as greater Working from Home (WFH) and active travel, present a unique opportunity to reimagine more sustainable transport systems. The aim of the current study was to develop a 2050 transport vision and identify short term priorities for Melbourne (Australia) based on in-depth stakeholder interviews. To the best of our knowledge, this is the first backcasting study since COVID-19. As the city with the 'longest lockdown', Melbourne has valuable lessons for the rest of the world. Overall, participants reported that they were uncertain about the future of the central business district. Participants envisaged that the transport system would be carbon-neutral or carbon-positive. However, private motor vehicles (including electric and automated) were not considered the solution for handling the scale of trips anticipated with the projected population size. Instead, participants perceived that in Melbourne by 2050, there will be less work-related travel due to greater job flexibility and WFH. More localised neighbourhood living (20-minute cities), with most short trips undertaken by active travel, and longer trips by public transport. Furthermore, it was projected that regional centres will grow and the transport system will be for the whole state of Victoria and not just Melbourne. Finally, the study identified short term (2021-2030) travel behaviour priorities and eight immediate actions, including: urban design focusing on inspiring active travel; reallocating road space to prioritise active and public transport modes; planning for micromobility urban freight; improving public transport services; expanding public transport networks; installing electric vehicle charging infrastructure; supporting WFH to encourage trip avoidance; and encouraging political consensus when building major transport projects.
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http://dx.doi.org/10.1016/j.tranpol.2022.12.022 | DOI Listing |
BMC Res Notes
January 2025
Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Alborz, Iran.
Adult T-cell leukemia/lymphoma (ATLL) is a type of blood cancer related to human T-cell lymphotropic virus type 1 (HTLV-1). The principal aim of this study was to investigate cellular processes related to innate immune response, intracellular protein transport, and translational initiation regulation in individuals afflicted with ATLL and Acute lymphoblastic leukemia (ALL). Whole blood samples and peripheral blood mononuclear cells were collected from 10 viral ATLL patients and 10 ALL subjects.
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January 2025
Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, 117549,Singapore.
This is a state-of-the-art review of historical developments, current approaches and recommended future directions in physical activity (PA) research, practice and policy. Since the early epidemiological studies in the 1950s, PA research has developed from within a biomedical paradigm. There is now a strong evidence base linking PA with positive health outcomes.
View Article and Find Full Text PDFAddict Biol
January 2025
Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Morphine dependence or addiction is a serious global public health and social problem, and traditional treatments are very limited. Deep brain stimulation (DBS) has emerged as a new potential treatment for drug addiction. Repeated use of morphine leads to neuroadaptive and molecular changes in the addiction-related brain regions.
View Article and Find Full Text PDFiScience
January 2025
Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Québec H7V 1B7, Canada.
During infection, dengue virus (DENV) and Zika virus (ZIKV), two (ortho)flaviviruses of public health concern worldwide, induce alterations of mitochondria morphology to favor viral replication, suggesting a viral co-opting of mitochondria functions. Here, we performed an extensive transmission electron microscopy-based quantitative analysis to demonstrate that both DENV and ZIKV alter endoplasmic reticulum-mitochondria contact sites (ERMC). This correlated at the molecular level with an impairment of ERMC tethering protein complexes located at the surface of both organelles.
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