AI Article Synopsis
- - The study assessed the effectiveness and safety of adalimumab (ADA) in treating chronic recurrent Vogt-Koyanagi-Harada (VKH) patients presenting with sunset glow fundus (SGF) over a period of more than 6 months.
- - A review of 50 patient medical records revealed significant improvements in visual acuity, flare counts, and other related measurements after ADA treatment, with a continued treatment rate of 94%.
- - The findings indicate that ADA is effective for remission in VKH patients who have not responded well to typical treatments, with a generally high tolerance for the medication and few serious side effects.
Article Abstract
Purpose: We investigated the efficacy and safety of adalimumab (ADA) treatment for chronic recurrent Vogt-Koyanagi-Harada (VKH) patients with sunset glow fundus (SGF).
Methods: Medical records of 50 chronic recurrent VKH patients with SGF who received ADA treatment for more than 6 months were retrospectively reviewed.
Results: The mean age of chronic recurrent VKH patients with SGF was 55.9 ± 14.4 years, and the male/female ratio was 26/24. Before ADA treatment, the mean daily dose of systemic corticosteroids was 16.5 ± 12.7 mg, and 22 patients (44%) were under immunosuppressors. LogMAR visual acuity (VA), flare counts, subfoveal choroidal thickness (SFCT), indocyanine green angiography scores, and corticosteroid and cyclosporine doses were significantly reduced by ADA treatment at 6 months compared to baseline. Among all parameters, flare count was significantly related to LogMAR VA. LogMAR VA was significantly related to flare counts but not to SFCT nor to ICGA scores. ADA treatment was continued in 94%.
Conclusion: ADA was shown to be effective in achieving remission of chronic recurrent VKH disease with SGF refractory to conventional treatments, and was generally well tolerated with few serious adverse events.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811924 | PMC |
| http://dx.doi.org/10.4103/sjopt.sjopt_204_22 | DOI Listing |
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