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Prognosis After Pathologic Complete Response to Neoadjuvant Therapy in Early-Stage Breast Cancer: A Population-Based Study.
J Natl Compr Canc Netw
March 2025
1Oncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.
Background: Pathologic complete response (pCR) following neoadjuvant chemotherapy (NACT) for early-stage breast cancer is prognostic, but not the sole surrogate marker for long-term outcome at a trial level, given that recurrence risk persists in patients who achieve pCR. This study aimed to investigate factors affecting the outcome of patients who achieve pCR.
Methods: This population-based cohort study prospectively enrolled patients who received NACT for nonmetastatic breast cancer between 2007 and 2020 in the Stockholm-Gotland region, which comprises 25% of the entire Swedish population.
Fungal Necrotizing Otitis Externa: Clinical and Therapeutic Features.
Ear Nose Throat J
March 2025
Department of Otorhinolaryngology, Tahar Sfar Hospital, Mahdia, Tunisia.
To describe the clinical and therapeutic features of fungal necrotizing otitis externa (NOE) as well as to identify the predictive factors of complications. This retrospective and monocentric study included 15 cases of fungal NOE treated in our ENT department between 2006 and 2024. Clinical, biological, microbiological, and imaging data were collected and evaluated.
View Article and Find Full Text PDFRisk Factors for Intrahepatic Distant Recurrence After Radiofrequency Ablation for Hepatocellular Carcinoma.
Dig Dis Sci
March 2025
Department of Gastroenterology of Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan.
Aim: The incidence of intrahepatic distant recurrence (IDR) of hepatocellular carcinoma (HCC) still remains high after radiofrequency ablation (RFA). However, serum alpha-fetoprotein (AFP) has insufficient screening power. This study aimed to identify risk factors for IDR in patients with post-RFA HCC.
View Article and Find Full Text PDFUse of biochemical and imaging criteria for selecting patients for prostate biopsy in recurrence risk assessment post-HIFU therapy.
World J Urol
March 2025
Desai Sethi Urology Institute, University of Miami, Miller School of Medicine, Miami, FL, USA.
Purpose: Despite the growing adoption of HIFU treatment for localized prostate cancer (PC), standardized criteria for evaluating success and predicting recurrence remain undefined. Herein, we analyze the predictive value of noninvasive tools such as PSA dynamics and MRI to determine recurrence.
Methods: We identified from our HIFU therapy prospective registry patients who developed biopsy-proven recurrence, between 2016 and 2023.
Prognostic value of interictal epileptiform discharges on routine EEG in adults with epilepsy.
Epilepsia
March 2025
Department of Neurosciences, University of Montreal, Montreal, Quebec, Canada.
Objective: To determine whether interictal epileptiform discharges (IEDs) on routine electroencephalography (EEG) predict seizure recurrence in adults with established epilepsy.
Methods: We conducted a retrospective survival analysis of consecutive adults with epilepsy undergoing routine EEG at a tertiary center between 2018 and 2019. Using multivariate Cox proportional hazards models guided by a directed acyclic graph and adjusted for confounders including past seizure frequency and duration of epilepsy, we estimated the association between the presence of IEDs and time to next seizure, stratified by epilepsy type.
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