Research progress on the role of (Nedd4 family interacting protein 1) in immune cells.

Nedd4 family interacting protein 1 () was first mentioned in an article in 2000. Since its discovery, related studies have shown that this protein is associated with apoptosis, neuroprotection, substance transport, ubiquitination, and immune regulation. It is noteworthy that the lack of can lead to death in fetal mice. Researchers generally believe that the function of is closely related to individual immune capacity and have published a large number of articles. However, a comprehensive classification of the immune regulatory function of is still lacking. In this review, we will overview and discuss this new perspective, focusing on the role of in the proliferation, differentiation, and cell activity of CD4 T cells, CD8 T cells, mast cells, and eosinophils. This review provides an updated summary of , which will unveil novel therapeutic targets. Finally, the conclusion is that mainly plays a negative regulatory role in immune cells by maintaining the stability of the immune response and limiting its overexpression.