Optical coherence tomography angiography with adaptive multi-time interval.

Optical coherence tomography angiography (OCTA) can provide in vivo three-dimensional microvasculature information of bio-tissues, but it is sensitive to motion and time-consuming. To overcome these limitations, we propose an adaptive multiple time interval correlation mapping OCTA with a time-efficient scanning protocol and motion compensation algorithms. A spectral-domain OCT with a center wavelength of 850 nm, A-scan rate of 120 kHz and spatial resolution of 4.1 μm (axial) × 6.9 μm (lateral) is built to reconstruct the microvascular networks in the human arm. By adaptive optimization of the weights of different time interval B-scan angiograms, our novel OCTA technique achieves better performance with a visible vascular density increase of ~67% and a signal-to-noise ratio enhancement of ~11.6%.