[Inflammatory markers, lipid metabolism and renal functional state in young, middle, elderly and senior patients with high cardiovascular risk.].

With increasing age in the human body, various pathophysiological changes are observed in response to the effects of various factors, taking into account the genetic predisposition. Among the possible factors causing an increase in cardiovascular risk in the general population are the level of blood pressure, changes in lipid metabolism and inflammation markers, as well as the magnitude of the filtration function of the kidneys. This publication examined inflammatory markers, lipid metabolism, and renal function in 269 (136 males and 133 females) young, middle, elderly, and senile patients at high cardiovascular risk. It was shown that among the elderly, the frequency of overweight was 31%. The prevalence of obesity of the 1st degree was relatively higher in patients of middle (25,4%) and elderly (28,7%) age. In senile (62,5%) and young (48,3%) people, the most frequently recorded increase in heart rate was ≥80 beats per minute. The prevalence of arterial hypertension was 31,6% in young people and 59,4% in middle-aged people. The number of patients with hypertension increased among the elderly and senile participants, 68,9 and 62,5% respectively. Systolic blood pressure levels were higher in the elderly compared to young and old people. The diastolic blood pressure and hemoglobin levels were significantly lower among elderly patients. Levels of total cholesterol, cholesterol of low density lipoproteins and triglycerides were significantly higher in middle-aged people. Serum levels of tumor necrosis factor-alpha (TNF-α), as well as C-reactive protein, were significantly higher among elderly patients. A significant decrease in the filtration function of the kidneys was observed among elderly and senile patients.