The variational optical flow model is used in this work to investigate a subgrid-scale optimization approach for modeling complex fluid flows in image sequences and estimating their two-dimensional velocity fields. To solve the problem of lack of sub-grid small-scale structure information in variational optical flow estimation, we combine the motion laws of incompressible fluids. Introducing the idea of large eddy simulation, the instantaneous motion can be decomposed into large-scale motion and a small-scale turbulence in the data term. The Smagorinsky model is used to model and solve the small-scale turbulence. The improved subgrid scale Horn-Schunck (SGS-HS) optical flow algorithm provides better results in velocity field estimation of turbulent image sequences than the traditional Farneback dense optical flow algorithm. To make the SGS-HS algorithm equally competent for the open channel flow measurement task, a velocity gradient constraint is chosen for the canonical term of the model, which is used to improve the accuracy of the SGS-HS algorithm in velocimetric experiments in the case of the relatively uniform flow direction of the open channel flow field. The experimental results show that our algorithm has better performance in open channel velocimetry compared with the conventional algorithm.
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http://dx.doi.org/10.3390/s23010437 | DOI Listing |
Eur J Nucl Med Mol Imaging
January 2025
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab govitecan-hziy (Trodelvy), has shown efficacy in targeting this antigen. Leveraging the enhanced specificity of ADCs, we conducted the first immunoPET imaging study of Trop2 expression in gastric cancer (GC) and triple-negative breast cancer (TNBC) models using Zr-labeled Trodelvy ([Zr]Zr-DFO-Trodelvy).
View Article and Find Full Text PDFWe present a widefield fluorescence microscope that integrates an event-based image sensor (EBIS) with a CMOS image sensor (CIS) for ultra-fast microscopy with spectral distinction capabilities. The EBIS achieves a temporal resolution of ∼10s (∼ 100,000 frames/s), while the CIS provides diffraction-limited spatial resolution. A diffractive optical element encodes spectral information into a diffractogram, which is recorded by the CIS.
View Article and Find Full Text PDFEmploying free-running laser/envelope detection-based millimeter wave (mmWave) signal generation/detection at remote radio heads (RRHs)/user equipment (UE) offers a cost-effective solution for seamlessly integrating existing intensity modulation-direct detection (IM-DD)-dominated optical access networks and wireless networks. Such fiber-wireless convergence enables a continuous flow of signals with varying characteristics between the baseband unit (BBU) and UE across fiber and wireless network segments without the need for optical-electrical-optical (O-E-O) conversions and digital signal processing (DSP) at intermediate nodes. In this paper, we extensively investigate the performance of such a fiber-wireless converged access network employing free-running laser/envelope detection-based mmWave generation/detection in an IM-DD-based 1.
View Article and Find Full Text PDFInt J Pharm
January 2025
School of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia.
Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition locations on deposition efficiency, they have not focused on the thickness of deposited particles, which can significantly affect drug dissolution, absorption and therapeutic efficacy. This study investigates the deposition patterns of dry powder particles within the nasal airway, specifically examining how factors such as flow rates, particle size, and particle cohesiveness influence deposition patterns and their thickness.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
January 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Electronic address:
Purpose: Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.
Methods: This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification.
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