Tires are one of the most basic and important components of vehicles, including bicycles, cars, trucks, and aircraft. They consist of several layers that provide complex and dynamically changing functions. This work aims to optimize the mounting process of the tire apex to the bead. The bead locks the tire to the rim and helps minimize the risk of rim slip, and the apex provides dynamic stiffness, stress distribution, and driving stability. In mounting the apex onto the bead, air can be trapped between the apex and bead, which is an undesirable and significant problem in tire manufacturing. An FE model was created to simulate and optimize this process. After modifying the apex dimensions, the air was displaced from the space between the apex and the bead. Based on the simulation results, a set of recommendations for producing suitable apex shapes is provided.
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http://dx.doi.org/10.3390/ma16010377 | DOI Listing |
Microorganisms
November 2024
Centre for Translational Medicine, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.
Automated nucleic acid extractors are useful instruments for the high-throughput processing of bio-samples and are expected to improve research throughput in addition to decreased inter-sample variability inherent to manual processing. We evaluated three commercial nucleic acid extractors Bioer GenePure Pro (Bioer Technology, Hangzhou, China), Maxwell RSC 16 (Promega Corporation, Madison, WI, USA), and KingFisher Apex (ThermoFisher Scientific, Waltham, MA, USA) based on their DNA yield, DNA purity, and 16S rRNA gene amplicon results using both human fecal samples and a mock community (ZymoBIOMICS Microbial Community Standard (Zymo Research Corp., Irvine, CA, USA)).
View Article and Find Full Text PDFExp Eye Res
December 2024
Department of Ophthalmology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Tear inflammatory cytokines are a novel biomarker studied in a range of ocular surface diseases, periorbital and orbital conditions. This single-centre prospective study between 2022 and 2024 aims to characterise tear cytokine profiles (Interleukin-1β [IL-1β], IL-2, IL-6, Interferon-γ [IFN-γ] and Tumour Necrosis Factor-α [TNF- α]) in orbital inflammatory disease (OID). OID patients had pre-treatment tear collection via micropipette, and cytokine analysis via multiplex bead array analysis.
View Article and Find Full Text PDFNanotechnology
June 2023
Department of Mechanical Engineering, Boston University, 110 Cummington Mall, Boston, Massachusetts, MA 02215, United States of America.
The ability to precisely pattern nanoscale amounts of liquids is essential for biotechnology and high-throughput chemistry, but controlling fluid flow on these scales is very challenging. Scanning probe lithography methods such as dip-pen nanolithography (DPN) provide a mechanism to write fluids at the nanoscale, but this is an open loop process as methods to provide feedback while patterning sub-pg features have yet to be reported. Here, we demonstrate a novel method for programmably nanopatterning liquid features at the fg-scale through a combination of ultrafast atomic force microscopy probes, the use of spherical tips, and inertial mass sensing.
View Article and Find Full Text PDFMed Phys
October 2023
Cancer Institute, Tehran University of Medical Science, Tehran, Iran.
Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic modalities, and nanomedicine has lately entered this field. Brachytherapy using Ruthenium-106 ( Ru) ophthalmic plaques has been used for decades to treat ocular melanoma, with the applicator placed on the patient's eyes until the prescribed dose reaches the tumor apex.
View Article and Find Full Text PDFMaterials (Basel)
December 2022
Department of Applied Mechanics and Mechanical Engineering, Faculty of Mechanical Engineering, Technical University of Kosice, 04001 Kosice, Slovakia.
Tires are one of the most basic and important components of vehicles, including bicycles, cars, trucks, and aircraft. They consist of several layers that provide complex and dynamically changing functions. This work aims to optimize the mounting process of the tire apex to the bead.
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