Skin ulceration is an important cause of morbidity in systemic sclerosis and can occur at anytime during disease progression. Incident disease cohorts are important for understanding whether skin ulceration represents active vasculopathy versus resultant damage. Biomarkers for skin ulcer pathogenesis, both serum and imaging, are under investigation to elucidate the functional consequences of the structural abnormalities. Novel therapeutics for the treatment of vasculopathy benefit from reliable biomarkers able to predict the disease evolution remains an important unmet need. Nonetheless, a diagnostic approach that captures early skin ulceration and treatments that restore vascular and immune homeostasis is critical for effective systemic sclerosis (SSc) vasculopathy management.
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http://dx.doi.org/10.1016/j.berh.2022.101813 | DOI Listing |
J Med Case Rep
December 2024
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
Background: Polyarteritis nodosa is a relatively uncommon type of systemic necrotizing vasculitis that primarily affects medium-sized arteries. While gastrointestinal involvement is known in polyarteritis nodosa, heavy gastrointestinal bleeding due to gastric ulceration is relatively uncommon. We present the case of an 81-year-old male of Chinese ethnicity who experienced severe gastrointestinal bleeding as a result of polyarteritis nodosa and an innovative treatment approach for a better patient outcomes.
View Article and Find Full Text PDFGenomics
December 2024
Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China; Department of Laboratory Medicine, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China. Electronic address:
Skin wound repair involves myofibroblasts crucial for tissue integrity. This study utilized single-cell RNA sequencing to explore myofibroblast diversity in various wound healing scenarios. Analysis of 89,148 cells from skin ulcers, keloids, and normal scars identified 14 cell clusters.
View Article and Find Full Text PDFEur J Med Res
December 2024
Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Background: Diabetes mellitus (DM) can cause severe complications, including diabetic foot ulcers (DFU). There is a significant gap in understanding the single-cell ecological atlas of DM and DFU tissues.
Methods: Single-cell RNA sequencing data were used to create a detailed single-cell ecological landscape of DM and DFU.
Int J Mycobacteriol
October 2024
Programme Department, RedAid, Enugu, Enugu State, Nigeria.
Background: Neglected tropical diseases (NTDs) significantly impact the physical and mental well-being of affected individuals, particularly in Nigeria. This study aims to evaluate the effectiveness of integrating mental health services with self-care practices for individuals suffering from leprosy, Buruli ulcer (BU), and lymphatic filariasis (LF). The role of trained Healthcare Workers (HCWs) and NTD champions (NTD-Cs) will be explored to enhance health outcomes in this population.
View Article and Find Full Text PDFRev Gaucha Enferm
December 2024
Universidade Federal do Rio Grande do Sul, Escola de Enfermagem. Porto Alegre, RS, Brasil.
Objective: To compare the incidence, characteristics, and risk factors of pressure injuries among critically ill patients with and without Covid-19 in an intensive care unit.
Method: Retrospective cohort study in an intensive care unit by collecting data from electronic medical records of patients admitted in 2021. Sample of 302 patients, 151 with Covid-19 and 151 without Covid-19.
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