In this issue of Molecular Cell, Yaneva et al. demonstrate that the DNA helicase FANCJ promotes DNA replication-coupled DNA-protein crosslink (DPC) repair via an unexpected ability to unfold the protein adduct, thereby enabling its proteolysis by the DPC protease SPRTN.
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| http://dx.doi.org/10.1016/j.molcel.2022.12.009 | DOI Listing |
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