AI Article Synopsis
- A study analyzed tonsils from 10 patients (ages 18-40) with chronic tonsillitis using histological methods and high-pressure liquid chromatography.
- In patients with more severe forms of the disease and heart issues, only mild changes were seen in tonsil structure, while those with frequent angina had significant cell destruction.
- All patients had increased levels of purine and pyrimidine derivatives, with those showing the most cell damage also producing higher amounts of xanthine and uric acid, which were absent in less affected patients.
Article Abstract
Tonsils from 10 patients (18-40 years old), with chronic tonsillitis were studied by means of histological methods as well as by high pressure liquid chromatography. In 5 patients with decompensated forms of the disease, accompanied by heart impairments during 1-3 years, only slight alterations in epithelial and follicular parts of tonsils were observed, while pronounced destruction of tonsil cells was detected in other 5 patients suffering from repeated anginas. The following purine and pyrimidine derivatives were identified in faucial tonsil tissue of all the patients with chronic tonsillitis studied: adenine, guanine, adenosine, guanosine, inosine and uridine. Distinct increase in content of these derivatives as well as occurrence of xanthine and uric acid (non-identified in the first group of patients with chronic tonsillitis) was noted in the patients with maximal destruction of faucial tonsil cells.
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