[This retracts the article DOI: 10.7150/jca.30143.].
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Retraction Note: 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells.
BMC Cancer
December 2023
Department of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
Retraction: 8-bromo-7-methoxychrysin targets NF-κB and FoxM1 to inhibit lung cancer stem cells induced by pro-inflammatory factors.
J Cancer
December 2022
Department of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
[This retracts the article DOI: 10.7150/jca.30143.
View Article and Find Full Text PDF8-bromo-7-methoxychrysin targets NF-κB and FoxM1 to inhibit lung cancer stem cells induced by pro-inflammatory factors.
J Cancer
August 2019
Department of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
We have previously reported that 8-bromo-7-methoxychrysin (BrMC), a novel synthetic derivative of chrysin, was demonstrated anti-tumor activities against several human cancers, including lung cancer. Interaction between inflammation and cancer stem cell are recently increasingly recognized in tumorigenesis and progression. The purpose of this study was to investigate whether BrMC inhibits lung cancer stemness of H460 cells induced by inflammatory factors (TGF-β combined with TNF-α) and its potential mechanism.
View Article and Find Full Text PDF8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells.
BMC Cancer
March 2019
Department of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
Background: Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX-2 that was activated by liver cancer stem-like cells (LCSCs). However, whether and whereby BrMC inhibits the stemness induced by co-culture of LCSCs and LX-2 cells remains to be investigated.
Methods: The second-generation spheres by sphere culture were identified and used as SMMC-7721-and MHCC97H-derived LCSLCs.
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