AI Article Synopsis
- Nematode cuticles serve as structural supports and barriers, and disruptions in their collagen or protein structures trigger stress response genes.
- The study emphasizes that most research on stress signaling has centered on adult nematodes, while this analysis explores all post-embryonic developmental stages.
- By examining mutant strains concerning specific collagen and epidermal proteins, the research aims to uncover how cuticle characteristics and stress responses develop throughout nematode growth.
Article Abstract
Nematode cuticles are extracellular matrices (ECMs) that function as structural support and permeability barriers. Genetic disruption of specific cuticle collagen structures or secreted epidermal proteins in activates stress response genes in epithelial cells suggesting the presence of an extracellular damage signaling mechanism. Cuticles are replaced during development molting but investigations of extracellular signaling to stress responses have focused on adults. In our current study, we measured cuticle phenotypes and stress response gene expression in all post-embryonic stages of mutant strains for a collagen and two secreted epidermal proteins to gain insights into developmental patterns.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807463 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000688 | DOI Listing |
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