AI Article Synopsis
- - Vincristine-induced peripheral neuropathy (VIPN) is a common side effect of the chemotherapy drug vincristine, and currently, there are no effective treatments to prevent or cure it.
- - A case study of a patient with severe VIPN demonstrated the use of pharmacogenetic analyses, examining genes related to vincristine metabolism and neurological diseases, revealing specific genetic polymorphisms.
- - The findings suggest that understanding genetic risk factors for VIPN could improve clinical practices, highlighting the need for early detection strategies to personalize treatment and minimize adverse effects.
Article Abstract
Vincristine-induced peripheral neuropathy (VIPN) is a common adverse effect of vincristine (VCR) for which there is no preventative or curative treatment. Here, we report a case of a patient suffering from severe VCR-related neurotoxicity. To explore the possible causes of severe VIPN in this patient, a set of genes involved in VCR metabolism, transport or are related to the cytoskeleton, microtubules, and inherited neurological diseases gene polymorphisms were examined via pharmacogenetic analyses. The genotyping results revealed the presence of a complex pattern of polymorphisms in , miR-4481 and miR-3117. A comprehensive understanding of all the pharmacogenetic risk factors for VIPN may explain the occurrence of severe neurotoxicity in our patient. This case brings to light the potential importance of pharmacogenetic testing in clinical practice. It also exemplifies the importance of developing early-detection strategies to optimize treatment regimens through prior risk stratification while reducing adverse drug reactions and personalizing therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809358 | PMC |
| http://dx.doi.org/10.2147/PGPM.S389197 | DOI Listing |
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