AI Article Synopsis
- Migraines are a neurological condition marked by severe headaches, and new research highlights the role of genetic variations, like CNVs and miRNA expression, in understanding and potentially treating this disease.
- A study with migraine sufferers (102 participants) and non-sufferers (120 participants) analyzed various genetic markers alongside clinical parameters, finding significant differences in specific genes and CNV patterns between the two groups.
- The analysis demonstrated that certain genetic markers had good diagnostic power, suggesting they might be used in developing targeted treatments for migraines by modulating pain mechanisms.
Article Abstract
Migraine is a neurological disease characterized by severe headache attacks. Combinations of different genetic variations such as copy number variation (CNV) in a gene and microRNA (miRNA) expression can provide a holistic approach to the disease as a pathophysiological, diagnostic, and therapeutic target. CNVs, the Cholinergic Receptor Nicotinic Alpha 7 Subunit () gene, and expression of gene-targeting miRNAs ( and ) in migraineurs ( = 102; with aura, = 43; without aura, = 59) and non-migraines ( = 120) aged 15-60 years, comparative, case-control study was conducted. Genetic markers were compared with biochemical parameters (BMI, WBC, Urea, GFR, ESR, CRP, HBG). All analyzes were performed by quantitative Real-Time PCR (q-PCR) and fold change was calculated with the 2 method. The diagnostic power of the gene, CNV, and miRNAs were analyzed with the receiver operating curve (ROC). gene and are down-regulated in migraineurs and the gene is controlled by this miRNA via CNVs ( < .05). Both deletion and duplication were detected in patients with migraine for CVN numbers ( = .05). The number of CNV deletions was higher than duplications. When -CNV- was modeled together in the ROC analysis, the area under the curve (AUC) was 0.805, and the diagnostic power was "good". In migraineurs, the gene can be controlled by via CNVs to modulate the mechanism of pain. These three genetic markers have diagnostic potential and may be used in antimigraine treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850133 | PMC |
| http://dx.doi.org/10.1177/17448069231152104 | DOI Listing |
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