AI Article Synopsis
- New psychoactive substances (NPS) are not regulated by international drug treaties but can pose public health risks, with insufficient knowledge about their toxic effects.
- Research conducted a literature review from 2017 to 2021, finding a significant lack of studies on the toxicity of many NPS, particularly concerning chronic and post-mortem effects, compared to acute toxicity.
- The study highlights the urgent need for more comprehensive research on the health threats posed by NPS and their polydrug use effects.
Article Abstract
Purpose: New psychoactive substances (NPS) are not controlled under the Single Convention on Narcotic Drugs of 1961 or the 1971 Convention, but they may pose a public health threat. Knowledge of the main properties and toxicological effects of these substances is lacking. According to the current Drugs Law (Law n. 11.343/2006), the Brazilian Surveillance Agency issues directives for forbidden substances in Brazil, and structural classes of synthetic cannabinoids, cathinones, and phenylethylamines are considered illicit drugs. Considering that data on these controlled substances are scattered, the main objective of this work was to collect and organize data to generate relevant information on the toxicological properties of NPS.
Methods: We carried out a literature review collecting information on the acute, chronic, and post-mortem toxicity of these classes of NSP. We searched info in five scientific databases considering works from 2017 to 2021 and performed a statistical evaluation of the data.
Results: Results have shown a general lack of studies in this field given that many NPS have not had their toxicity evaluated. We observed a significant difference in the volume of data concerning acute and chronic/post-mortem toxicity. Moreover, studies on the adverse effects of polydrug use are scarce.
Conclusions: More in-depth information about the main threats involving NPS use are needed.
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| http://dx.doi.org/10.1007/s11419-022-00657-3 | DOI Listing |
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