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Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes.
J Pathol Transl Med
November 2024
Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Article Synopsis
- * This review outlines the distinct cytological traits of multiple PTC subtypes, emphasizing the importance of recognizing them to identify more aggressive forms that are associated with worse prognoses.
- * It also discusses the potential of molecular testing to improve diagnosis and treatment, while stressing the need for better diagnostic techniques in the evaluation of thyroid cancer.
Clinical and Histopathological Features of Thyroid Cancer with Promoter Molecular Alterations in Isolation Versus with Concurrent Molecular Alterations: A Multicenter Retrospective Study.
Cancers (Basel)
October 2024
Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Article Synopsis
- Molecular testing of thyroid nodules helps identify genetic changes that can indicate the risk of cancer aggressiveness and behavior.
- The study looked at patients from 2017 to 2024, focusing on those with specific mutations and analyzing their association with aggressive thyroid cancer types.
- Results showed that patients with both TEL mutations and concurrent alterations were more likely to have high-risk features and aggressive cancer forms, while TEL mutations alone showed a tendency for less aggressive behavior.
Cytologic and Clinicopathologic Features of Papillary Thyroid Carcinoma with Prominent Hobnail Features on FNAC.
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Otolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand India.
The hobnail variation of papillary thyroid cancer (PTC) is an uncommon, aggressive variety with hobnail characteristics on more than 30% of the tumour cells. Because of the entity's rarity, the clinical behaviour and pathologic characteristics of these tumours are still unknown. The purpose of this case study was to look at the cytologic, clinical, and pathological aspects of the hobnail variant of PTC, because of its severe clinicopathologic features and poor outcome, the unusual hobnail type of PTC may necessitate more aggressive treatment than traditional PTCs.
View Article and Find Full Text PDFPersistent Thrombotic Hemangioma With Organizing/Anastomosing Features: A Case Report of a Guanine Nucleotide-Binding Protein Alpha Subunit (GNA)-Mutated Cutaneous Vascular Lesion.
Cureus
September 2024
Dermatopathology Section, Regional Medical Laboratory and Pathology Laboratory Associates, Tulsa, USA.
Article Synopsis
- Thrombotic hemangioma with organizing/anastomosing features (THOA) is a newly recognized variant of hemangioma linked to mutations in GNA genes, displaying unique clinical and morphological traits.
- Although it shows benign behavior, histological features may cause concerns for a low-grade malignant vascular neoplasm.
- A case study of a 74-year-old woman revealed persistent THOA through next-generation sequencing, identifying specific gene mutations and contributing to understanding the lesion's characteristics and prognosis.
Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings.
Eur Thyroid J
October 2024
Department of Surgery, Kuma Hospital, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, Japan.
Article Synopsis
- Papillary thyroid carcinoma (PTC) is primarily diagnosed through preoperative cytology, with factors like tumor size and metastasis significantly affecting its prognosis; certain aggressive variants also play a role in expected outcomes.
- Follicular thyroid carcinoma (FTC) is typically assessed post-surgery, with various invasive classifications influencing prognosis—vascular invasion is a critical factor, affecting outcomes more than capsular invasion.
- Monitoring dynamic markers post-surgery, such as thyroglobulin-doubling rate, is vital for evaluating treatment effectiveness and providing follow-up care for patients with thyroid carcinomas.
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